De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives
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DOI: 10.1021/acs.jmedchem.9b00454
Abstract: Targeted protein degradation via cereblon (CRBN), a substrate receptor of an E3 ubiquitin ligase complex, is an increasingly important strategy in various clinical settings, in which the substrate specificity of CRBN is altered via the… read more here.
Keywords: crbn effectors; crbn; cereblon crbn; substrate ... See more keywords