Mining the CRBN target space redefines rules for molecular glue-induced neosubstrate recognition.
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DOI: 10.1126/science.adt6736
Abstract: The CRL4CRBN E3 ubiquitin ligase is the target of molecular glue degrader compounds that reprogram ligase specificity to induce the degradation of clinically relevant neosubstrate proteins. Known cereblon (CRBN) neosubstrates share a generalizable β-hairpin G-loop… read more here.
Keywords: crbn target; molecular glue; crbn; target ... See more keywords