Colorectal Cancer Screening Starting at Age 45 Years-Ensuring Benefits Are Realized by All.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2021.12593
Abstract: The latest recommendations from the US Preventive Services Task Force (USPSTF) represent a significant change in the scope of colorectal cancer (CRC) screening.1-3 For the first time, the USPSTF recommends initiating average-risk CRC screening at… read more here.
Keywords: age; colorectal cancer; among individuals; age years ... See more keywords
Association of Systemic Inflammation and Sarcopenia With Survival in Nonmetastatic Colorectal Cancer: Results From the C SCANS Study
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2017.2319
Abstract: Importance Systemic inflammation and sarcopenia are easily evaluated, predict mortality in many cancers, and are potentially modifiable. The combination of inflammation and sarcopenia may be able to identify patients with early-stage colorectal cancer (CRC) with… read more here.
Keywords: sarcopenia; inflammation; cancer; crc ... See more keywords
Age at Initiation of Lower Gastrointestinal Endoscopy and Colorectal Cancer Risk Among US Women.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.0883
Abstract: Importance In the past 4 years, the American Cancer Society and the US Preventive Services Task Force updated recommendations to initiate colorectal cancer (CRC) screening at 45 years of age to address the increasing incidence… read more here.
Keywords: endoscopy; years age; age; crc ... See more keywords
Progranulin sustains STAT3 hyper‐activation and oncogenic function in colorectal cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12552
Abstract: Persistent activation of Signal Transducer and Activator of Transcription (STAT)3 occurs in a high percentage of tumors, including colorectal cancer (CRC), thereby contributing to malignant cell proliferation and survival. Although STAT3 is recognized as an… read more here.
Keywords: colorectal cancer; hyper activation; activation; cancer cells ... See more keywords
Multiplex screening of 275 plasma protein biomarkers to identify a signature for early detection of colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12591
Abstract: Blood‐based protein biomarkers may be an attractive option for early detection of colorectal cancer (CRC). Here, we used a two‐stage design to measure 275 protein markers by proximity extension assay (PEA), first in plasma samples… read more here.
Keywords: protein; early detection; detection colorectal; crc ... See more keywords
Secretogranin II impairs tumor growth and angiogenesis by promoting degradation of hypoxia-inducible factor-1α in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13044
Abstract: Distant metastasis is a major cause of death in patients with colorectal cancer (CRC), but the management of advanced and metastatic CRC still remains problematic due to the distinct molecular alterations during tumor progression. Tumor… read more here.
Keywords: tumor; factor; crc; scg2 ... See more keywords
Viruses in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13100
Abstract: Increasing evidence suggests that microorganisms might represent at least highly interesting co-factors in colorectal cancer (CRC) oncogenesis and progression. Still, associated mechanisms, specifically in colonocytes and their microenvironmental interactions, are still poorly understood. Although, currently,… read more here.
Keywords: cells also; viruses colorectal; colorectal cancer; crc ... See more keywords
DCZ0415, a small‐molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β‐catenin pathway in colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13201
Abstract: Thyroid receptor‐interacting protein 13 (TRIP13), a protein of the AAA‐ATPase family, is upregulated in various human cancers, including colorectal cancer (CRC). This study focused on the inhibition of TRIP13‐induced CRC progression and signalling by DCZ0415,… read more here.
Keywords: wnt catenin; trip13; dcz0415; crc ... See more keywords
NICD3 regulates the expression of MUC5AC and MUC2 by recruiting SMARCA4 and is involved in the differentiation of mucinous colorectal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13296
Abstract: Adenocarcinoma is the most prevalent histological subtype of colorectal cancer (CRC), with mucinous colorectal adenocarcinoma (MCA) being a unique form. Although the mucinous subtype is known to elicit a worse response to chemotherapy and immunotherapy… read more here.
Keywords: colorectal adenocarcinoma; mucinous colorectal; crc; muc5ac muc2 ... See more keywords
Effects of high‐fat diet‐induced adipokines and cytokines on colorectal cancer development
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12751
Abstract: Colorectal cancer (CRC) is the third most common tumor worldwide, and recent epidemiological studies have indicated that obesity contributes to the morbidity and mortality of CRC. Furthermore, obesity‐related adipokines have been shown to be closely… read more here.
Keywords: fat diet; diet induced; adipokines cytokines; induced adipokines ... See more keywords
Targeting YAP1/LINC00152/FSCN1 Signaling Axis Prevents the Progression of Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Science"
DOI: 10.1002/advs.201901380
Abstract: Abstract As a transcription coactivator, Yes‐associated protein 1 (YAP1)'s role in tumorigenesis is well established. However, the mechanism of YAP1‐regulating long noncoding RNAs (lncRNA) in tumors is still largely unknown. Here, a YAP1 target gene,… read more here.
Keywords: linc00152 fscn1; colorectal cancer; crc; yap1 linc00152 ... See more keywords