Targeting of MAD2L1 by miR-515-5p involves the regulation of cell cycle arrest and apoptosis of colorectal cancer cells.
Sign Up to like & getrecommendations! Published in 2022 at "Cell biology international"
DOI: 10.1002/cbin.11774
Abstract: Although many previous studies have found that the mitotic arrest deficient 2-like 1 (MAD2L1) protein contributes to the proliferation of colorectal cancer (CRC) cells, but the upstream mechanism of MAD2L1 is still largely elusive. This… read more here.
Keywords: arrest; mad2l1; mir 515; cell ... See more keywords
EVs delivery of miR-1915-3p improves the chemotherapeutic efficacy of oxaliplatin in colorectal cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-021-04348-5
Abstract: Oxaliplatin is a crucial component of the combinatorial chemotherapeutic standard of care for advanced colorectal cancer (CRC). Unfortunately, a serious barrier to effective oxaliplatin treatment is drug resistance due to epithelial-mesenchymal transitioning (EMT). Interestingly, stable… read more here.
Keywords: crc cells; mir 1915; crc; cancer ... See more keywords
Encorafenib enhances TRAIL-induced apoptosis of colorectal cancer cells dependent on p53/PUMA signaling
Sign Up to like & getrecommendations! Published in 2020 at "Cytotechnology"
DOI: 10.1007/s10616-020-00442-3
Abstract: TRAIL has been demonstrated to play a critical role in the apoptosis of colorectal cancer (CRC) cells, but drug resistance markedly restricts its therapeutic effects. Objectives: This study aims to investigate whether encorafenib can enhance… read more here.
Keywords: trail; crc cells; trail induced; p53 puma ... See more keywords
LncRNA KCNQ1OT1 acts as miR-216b-5p sponge to promote colorectal cancer progression via up-regulating ZNF146
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Histology"
DOI: 10.1007/s10735-020-09942-0
Abstract: Long non-coding RNAs (lncRNAs) have shown to act as important regulators in cancer biology. The aim of this study was to investigate the role and mechanism of lncRNA KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) in… read more here.
Keywords: crc cells; mir 216b; znf146; kcnq1ot1 ... See more keywords
The Anticancer Effect of a Conjugated Antimicrobial Peptide Against Colorectal Cancer (CRC) Cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastrointestinal Cancer"
DOI: 10.1007/s12029-021-00799-4
Abstract: Although antimicrobial peptides (AMPs) were initially known as compounds of the innate immune system to fight microbial pathogens, it has been recently proposed that differences in normal and cancer cell membranes cause the anticancer effect… read more here.
Keywords: cancer; peptide; anticancer effect; crc cells ... See more keywords
Use Chou's 5-steps rule to study how Baicalin suppresses the malignant phenotypes and induces the apoptosis of colorectal cancer cells.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108919
Abstract: Baicalin is a traditional Chinese herb purified from the root of Scutellaria baicalensis Georgi. In this study, we further analyzed the molecular mechanism behind the anti-tumor activity of Baicalin in colorectal cancer (CRC). The establishment… read more here.
Keywords: crc cells; baicalin; colorectal cancer; mir 761 ... See more keywords
Gab3 is required for human colorectal cancer cell proliferation.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.095
Abstract: Here, we focused on the potential function of Gab3, an uncommon Gab family protein, in human colorectal cancer (CRC) cells. We found that Gab3 was only expressed in human colon cancer tissues as well as… read more here.
Keywords: gab3; crc cells; cell proliferation; cancer ... See more keywords
Nicotine-derived NNK induces the stemness enrichment of CRC cells through regulating the balance of DUSP4-ERK1/2 feedback loop.
Sign Up to like & getrecommendations! Published in 2021 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2021.112057
Abstract: Cigarette smoking has been considered as an independent risk factor for colorectal cancer (CRC) initiation and progression. In this study, we found that cigarette smoking was significantly associated with poor CRC differentiation (P = 0.040). Since studies… read more here.
Keywords: crc cells; nicotine derived; stemness enrichment; crc ... See more keywords
A new chalcone derivative, 3‐phenyl‐1‐(2,4,6‐tris(methoxymethoxy)phenyl)prop‐2‐yn‐1‐one), inhibits phorbol ester‐induced metastatic activity of colorectal cancer cells through upregulation of heme oxygenase‐1
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.10.011
Abstract: ABSTRACT Chalcone (1,3‐diphenyl‐2‐propen‐1‐one) derivatives exert anti‐cancer activity by targeting key molecules that can lead to carcinogenesis. We synthesized the chalcone derivative 3‐phenyl‐1‐(2,4,6‐tris(methoxymethoxy)phenyl)prop‐2‐yn‐1‐one (KB‐34) and previously reported its anti‐inflammatory activity in macrophages. In this study, we… read more here.
Keywords: crc cells; phenyl; cancer; activity ... See more keywords
β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0170-y
Abstract: Nuclear activated β-catenin plays a causative role in colorectal cancers (CRC) but remains an elusive therapeutic target. Using human CRC cells harboring different Wnt/β-catenin pathway mutations in APC/KRAS or β-catenin/KRAS genes, and both genetic and… read more here.
Keywords: crc cells; catenin knockdown; catenin; promotes nherf1 ... See more keywords
Bidirectional tumor/stroma crosstalk promotes metastasis in mesenchymal colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-1157-z
Abstract: Patients with the mesenchymal subtype colorectal cancer (CRC) have a poor prognosis, in particular patients with stroma-rich tumors and aberrant SMAD4 expression. We hypothesized that interactions between SMAD4-deficient CRC cells and cancer-associated fibroblasts provide a… read more here.
Keywords: crc cells; metastasis; smad4 deficient; crc ... See more keywords