Mechanically and chemically defined hydrogel matrices for patient-derived colorectal tumor organoid culture.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.119400
Abstract: Patient-derived tumor organoids offer potentially useful models of cancer tissue physiology. Yet, conventional organoid cultures utilize generic matrices that are difficult to tailor for various unique tumor microenvironments. Here, we employ synthetic, enzymatically crosslinked hydrogels… read more here.
Keywords: tumor; mechanically chemically; crc pdx; defined hydrogel ... See more keywords
Engineered colorectal cancer tissue recapitulates key attributes of a patient-derived xenograft tumor line
Sign Up to like & getrecommendations! Published in 2022 at "Biofabrication"
DOI: 10.1088/1758-5090/ac73b6
Abstract: The development of physiologically relevant in vitro colorectal cancer (CRC) models is vital for advancing understanding of tumor biology. Although CRC patient-derived xenografts (PDXs) recapitulate key patient tumor characteristics and demonstrate high concordance with clinical… read more here.
Keywords: ecrc pdx; pdx tumors; pdx tissues; crc pdx ... See more keywords