METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1
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DOI: 10.1038/s41417-024-00731-5
Abstract: Ran GTPase activating protein 1 (RanGAP1) has been implicated in various diseases, but its role in colorectal cancer (CRC) progression remains unclear. Using tumor tissues and public databases, we found that RanGAP1 was significantly upregulated… read more here.
Keywords: cancer; progression; rangap1; crc progression ... See more keywords
Identification of progression related LncRNAs in colorectal cancer aggressiveness
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DOI: 10.1038/s41598-025-02096-7
Abstract: Colorectal cancer (CRC) progression involves complex molecular alterations, including the dysregulation of long non-coding RNAs (lncRNAs). In this study, we identified key progression-related lncRNAs in CRC by integrating transcriptomic data from TCGA and single-cell RNA… read more here.
Keywords: colorectal cancer; related lncrnas; progression related; progression ... See more keywords
Exosomal circEIF3K from cancer-associated fibroblast promotes colorectal cancer (CRC) progression via miR-214/PD-L1 axis
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DOI: 10.1186/s12885-021-08669-9
Abstract: Background Tumor microenvironment (e.g., cancer-associated fibroblast) plays a key role in cancer tumorigenesis and metastasis. However, the detailed mechanism of whether hypoxia promotes CRC progression via tumor microenvironment remains unclear. Methods In this study, circEIF3K… read more here.
Keywords: progression via; circeif3k; mir 214; cancer ... See more keywords
PPIF+ neutrophils promote mtROS driven NETosis mediated progression of colorectal cancer
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DOI: 10.1186/s12967-025-07267-8
Abstract: To elucidate the mechanism through which tumor-associated neutrophil extracellular traps (NETs) contribute to the progression of colorectal cancer (CRC), characterize cellular populations within the CRC tumor microenvironment (TME), and identify potential therapeutic targets. We retrieved… read more here.
Keywords: colorectal cancer; progression colorectal; progression; crc ... See more keywords
The role of MARCH9 in colorectal cancer progression
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DOI: 10.3389/fonc.2022.906897
Abstract: Colorectal cancer (CRC) is the third most common cancer with a high global incidence and mortality. Mutated genes or dysregulated pathways responsible for CRC progression have been identified and employed as biomarkers for diagnosis and… read more here.
Keywords: march9; crc progression; colorectal cancer; cancer ... See more keywords