Coupling of binding and differential subdomain folding of the intrinsically disordered transcription factor CREB
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14554
Abstract: The cyclic AMP response element binding protein (CREB) contains a basic leucine zipper motif (bZIP) that forms a coiled coil structure upon dimerization and specific DNA binding. Although this state is well characterized, key features… read more here.
Keywords: dna; coupling binding; dna binding; binding differential ... See more keywords
Aluminum toxicity related to SOD and expression of presenilin and CREB in Bombyx mori.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.21480
Abstract: Aluminum (Al) is an important environmental metal factor that can be potentially associated with pathological changes leading to neurotoxicity. The silkworm, Bombyx mori, is an important economic insect and has also been used as a… read more here.
Keywords: bombyx mori; expression presenilin; creb; physiology ... See more keywords
Novel involvement of PLD–PKCδ–CREB axis in regulating FGF‐2‐mediated pentraxin 3 production in human nasal fibroblast cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30657
Abstract: A higher expression level of mitogenic fibroblast growth factor‐2 (FGF‐2) has been reported in human nasal mucus of both chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). Meanwhile, we have… read more here.
Keywords: creb; pkc creb; fgf; human nasal ... See more keywords
CREB activity is required for epidermal growth factor‐induced mouse cumulus expansion
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23285
Abstract: The release of a fertilizable oocyte from the ovary is dependent upon the expansion of the cumulus cells. The expansion requires cooperation between epidermal growth factor (EGF) family peptide‐activated mitogen‐activated protein kinase (MAPK)3/1 and oocyte… read more here.
Keywords: expansion; egf; creb; factor ... See more keywords
Dammarane sapogenins attenuates stress‐induced anxiety‐like behaviors by upregulating ERK/CREB/BDNF pathways
Sign Up to like & getrecommendations! Published in 2020 at "Phytotherapy Research"
DOI: 10.1002/ptr.6713
Abstract: Dammarane sapogenins (DS), an extract derived from ginseng by alkaline hydrolysis of total ginsenosides, possesses high pharmacological activity and higher bioavailability than ginsenosides. The present study was designed to investigate the anxiolytic‐like effects of DS… read more here.
Keywords: creb bdnf; anxiety like; creb; erk creb ... See more keywords
The adenosine A(2A) receptor agonist CGS 21680 alleviates auditory sensorimotor gating deficits and increases in accumbal CREB in rats neonatally treated with quinpirole
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05631-8
Abstract: The adenosine A(2A) receptor forms a mutually inhibitory heteromer with the dopamine D2 receptor, and A(2A) agonists decrease D2 signaling. This study analyzed whether an adenosine A(2A) agonist would alleviate deficits in sensorimotor gating and… read more here.
Keywords: agonist; sensorimotor gating; cgs 21680; adenosine receptor ... See more keywords
Glucosamine abrogates the stem cell factor + endothelin-1-induced stimulation of melanogenesis via a deficiency in MITF expression due to the proteolytic degradation of CREB in human melanocytes
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Dermatological Research"
DOI: 10.1007/s00403-018-1850-8
Abstract: We have already reported that glucosamine (GlcN) distinctly abrogates the pigmentation of human epidermal equivalents stimulated by stem cell factor + endothelin-1 (SE). In this study, we characterized the molecular mechanism involved in the anti-melanogenic effects of… read more here.
Keywords: mitf; glcn; stimulation; creb ... See more keywords
Up-regulation of Ca2+/CaMKII/CREB signaling in salicylate-induced tinnitus in rats
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3314-z
Abstract: The purpose of the study was to investigate the changes of Ca2+/calmodulin-dependent protein kinases II (CaMKII)/cAMP response element-binding protein (CREB) signaling pathway in a rat tinnitus model. Eighteen Wistar rats were randomly divided into three… read more here.
Keywords: creb; creb signaling; camkii; tinnitus model ... See more keywords
Roflumilast ameliorates cognitive impairment in APP/PS1 mice via cAMP/CREB/BDNF signaling and anti-neuroinflammatory effects
Sign Up to like & getrecommendations! Published in 2018 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-018-0374-4
Abstract: Phosphodiesterase type 4 (PDE4) inhibitors can prevent the breakdown of the second messenger cyclic adenosine monophosphate (cAMP) and improve cognitive performances in several animal models of cognition. However, the clinical development of PDE4 inhibitors has… read more here.
Keywords: creb; app ps1; camp; mice ... See more keywords
Dichloroacetic acid-induced dysfunction in rat hippocampus and the protective effect of curcumin.
Sign Up to like & getrecommendations! Published in 2021 at "Metabolic brain disease"
DOI: 10.1007/s11011-020-00657-5
Abstract: The present study was designed to evaluate the role of cAMP-PKA-CREB signaling in mediating the neuroprotective effects of curcumin against DCAA-induced oxidative stress, inflammation and impaired synaptic plasticity in rats. Sixty Sprague-Dawley rats were randomly… read more here.
Keywords: camp; creb; dcaa; dcaa induced ... See more keywords
Down-Regulated CUEDC2 Increases GDNF Expression by Stabilizing CREB Through Reducing Its Ubiquitination in Glioma.
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemical research"
DOI: 10.1007/s11064-020-03140-w
Abstract: Abnormally high expression of glial cell line-derived neurotrophic factor (GDNF) derived from glioma cells has essential impacts on gliomagenesis and development, but the molecular basis underlying increased GDNF expression in glioma cells remain unclear. This work… read more here.
Keywords: glioma; creb; expression; glioma cells ... See more keywords