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   Articles with "creb" as a keyword



Coupling of binding and differential subdomain folding of the intrinsically disordered transcription factor CREB

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14554

Abstract: The cyclic AMP response element binding protein (CREB) contains a basic leucine zipper motif (bZIP) that forms a coiled coil structure upon dimerization and specific DNA binding. Although this state is well characterized, key features… read more here.

Keywords: dna; coupling binding; dna binding; binding differential ... See more keywords

Aluminum toxicity related to SOD and expression of presenilin and CREB in Bombyx mori.

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recommendations! Published in 2018 at "Archives of insect biochemistry and physiology"

DOI: 10.1002/arch.21480

Abstract: Aluminum (Al) is an important environmental metal factor that can be potentially associated with pathological changes leading to neurotoxicity. The silkworm, Bombyx mori, is an important economic insect and has also been used as a… read more here.

Keywords: bombyx mori; expression presenilin; creb; physiology ... See more keywords

Vinpocetine Alleviates Valproic Acid‐Induced Hepatotoxicity and Neurotoxicity Through Activation of cAMP and PI3K/AKT/CREB Pathway in Rats

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recommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"

DOI: 10.1002/jbt.70316

Abstract: Valproic acid (VPA) is a frequently prescribed treatment for many psychiatric disorders, particularly for epilepsy. However, it has been associated with possible side effects including hepatotoxicity and neurotoxicity. The present study investigated the protective effect… read more here.

Keywords: vpa; camp; creb; pi3k akt ... See more keywords

Novel involvement of PLD–PKCδ–CREB axis in regulating FGF‐2‐mediated pentraxin 3 production in human nasal fibroblast cells

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recommendations! Published in 2021 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.30657

Abstract: A higher expression level of mitogenic fibroblast growth factor‐2 (FGF‐2) has been reported in human nasal mucus of both chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). Meanwhile, we have… read more here.

Keywords: creb; pkc creb; fgf; human nasal ... See more keywords

The interaction of RELN–DNMT genes involving in neurotrophin signaling pathway contributes to schizophrenia susceptibility

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recommendations! Published in 2024 at "International Journal of Developmental Neuroscience"

DOI: 10.1002/jdn.10316

Abstract: Schizophrenia belongs to a severe mental illness with complicated clinical presentations, an ill‐defined pathogenesis, and no known cause. Many genetic studies imply that polygenic interaction is important in the development of schizophrenia. The main mechanism… read more here.

Keywords: schizophrenia; dnmt; creb; interaction ... See more keywords

CREB activity is required for epidermal growth factor‐induced mouse cumulus expansion

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recommendations! Published in 2019 at "Molecular Reproduction and Development"

DOI: 10.1002/mrd.23285

Abstract: The release of a fertilizable oocyte from the ovary is dependent upon the expansion of the cumulus cells. The expansion requires cooperation between epidermal growth factor (EGF) family peptide‐activated mitogen‐activated protein kinase (MAPK)3/1 and oocyte… read more here.

Keywords: expansion; egf; creb; factor ... See more keywords

Dammarane sapogenins attenuates stress‐induced anxiety‐like behaviors by upregulating ERK/CREB/BDNF pathways

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recommendations! Published in 2020 at "Phytotherapy Research"

DOI: 10.1002/ptr.6713

Abstract: Dammarane sapogenins (DS), an extract derived from ginseng by alkaline hydrolysis of total ginsenosides, possesses high pharmacological activity and higher bioavailability than ginsenosides. The present study was designed to investigate the anxiolytic‐like effects of DS… read more here.

Keywords: creb bdnf; anxiety like; creb; erk creb ... See more keywords

The adenosine A(2A) receptor agonist CGS 21680 alleviates auditory sensorimotor gating deficits and increases in accumbal CREB in rats neonatally treated with quinpirole

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recommendations! Published in 2020 at "Psychopharmacology"

DOI: 10.1007/s00213-020-05631-8

Abstract: The adenosine A(2A) receptor forms a mutually inhibitory heteromer with the dopamine D2 receptor, and A(2A) agonists decrease D2 signaling. This study analyzed whether an adenosine A(2A) agonist would alleviate deficits in sensorimotor gating and… read more here.

Keywords: agonist; sensorimotor gating; cgs 21680; adenosine receptor ... See more keywords

Glucosamine abrogates the stem cell factor + endothelin-1-induced stimulation of melanogenesis via a deficiency in MITF expression due to the proteolytic degradation of CREB in human melanocytes

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recommendations! Published in 2018 at "Archives of Dermatological Research"

DOI: 10.1007/s00403-018-1850-8

Abstract: We have already reported that glucosamine (GlcN) distinctly abrogates the pigmentation of human epidermal equivalents stimulated by stem cell factor + endothelin-1 (SE). In this study, we characterized the molecular mechanism involved in the anti-melanogenic effects of… read more here.

Keywords: mitf; glcn; stimulation; creb ... See more keywords

Up-regulation of Ca2+/CaMKII/CREB signaling in salicylate-induced tinnitus in rats

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recommendations! Published in 2018 at "Molecular and Cellular Biochemistry"

DOI: 10.1007/s11010-018-3314-z

Abstract: The purpose of the study was to investigate the changes of Ca2+/calmodulin-dependent protein kinases II (CaMKII)/cAMP response element-binding protein (CREB) signaling pathway in a rat tinnitus model. Eighteen Wistar rats were randomly divided into three… read more here.

Keywords: creb; creb signaling; camkii; tinnitus model ... See more keywords

Roflumilast ameliorates cognitive impairment in APP/PS1 mice via cAMP/CREB/BDNF signaling and anti-neuroinflammatory effects

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recommendations! Published in 2018 at "Metabolic Brain Disease"

DOI: 10.1007/s11011-018-0374-4

Abstract: Phosphodiesterase type 4 (PDE4) inhibitors can prevent the breakdown of the second messenger cyclic adenosine monophosphate (cAMP) and improve cognitive performances in several animal models of cognition. However, the clinical development of PDE4 inhibitors has… read more here.

Keywords: creb; app ps1; camp; mice ... See more keywords