Suppression of phosphodiesterase IV enzyme by roflumilast ameliorates cognitive dysfunction in aged rats after sevoflurane anaesthesia via PKA‐CREB and MEK/ERK pathways
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DOI: 10.1111/ejn.15751
Abstract: Postoperative cognitive dysfunction (POCD) is a prevalent disorder after anaesthesia in the elderly patients. Roflumilast (RF), a phosphodiesterase 4 (PDE‐4) inhibitor, could improve cognition with no side effects. Here, we sought to explore the efficacy… read more here.
Keywords: pka creb; creb mek; mek erk;