Abstract 1577: GRK3 is a direct target of ADT-induced CREB1 activation and it promotes neuroendocrine differentiation of prostate cancer cells
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DOI: 10.1158/1538-7445.am2017-1577
Abstract: Treatment-related neuroendocrine prostate cancer (t-NEPC) is an aggressive subtype of prostate cancer that is believed to arise through neuroendocrine differentiation (NED) from prostate adenocarcinoma (PAC) upon castration resistance to androgen deprivation treatment (ADT). t-NEPC is… read more here.
Keywords: neuroendocrine differentiation; prostate cancer; grk3; creb1 activation ... See more keywords