Inhibiting H3K27 Demethylases Downregulates CREB‐CREBBP, Overcoming Resistance in Relapsed Acute Lymphoblastic Leukemia
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DOI: 10.1002/cam4.70596
Abstract: CREB binding protein (CREBBP) is a key epigenetic regulator, altered in a fifth of relapsed cases of acute lymphoblastic leukemia (ALL). Selectively targeting epigenetic signaling may be an effective novel therapeutic approach to overcome drug… read more here.
Keywords: resistance; acute lymphoblastic; lymphoblastic leukemia; crebbp ... See more keywords
CREB-binding protein (CREBBP) and preeclampsia: a new promising target gene.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06215-1
Abstract: Preeclampsia (PE) is a major complication of pregnancy and remains a leading cause of neonatal and maternal mortality worldwide. Several studies have revealed that the incidence of preeclampsia is high in mothers who carried a… read more here.
Keywords: crebbp; promising target; expression; gene ... See more keywords
Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment
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DOI: 10.1038/s41467-024-47012-1
Abstract: Despite regulating overlapping gene enhancers and pathways, CREBBP and KMT2D mutations recurrently co-occur in germinal center (GC) B cell-derived lymphomas, suggesting potential oncogenic cooperation. Herein, we report that combined haploinsufficiency of Crebbp and Kmt2d induces… read more here.
Keywords: crebbp kmt2d; crebbp; cell; lymphomagenesis ... See more keywords
CREBBP inactivation sensitizes B cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition
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DOI: 10.1038/s41467-025-59531-6
Abstract: B-cell acute lymphoblastic leukemia (B-ALL) is a leading cause of death in childhood and outcomes in adults remain dismal. There is therefore an urgent clinical need for therapies that target the highest risk cases. Mutations… read more here.
Keywords: acute lymphoblastic; lymphoblastic leukemia; crebbp; cell ... See more keywords
Regulation of RB1CC1/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region.
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2148432
Abstract: RB1CC1/FIP200 is an essential macroautophagy/autophagy protein that plays an important role in a variety of biological and disease processes through its canonical autophagy-dependent and -independent functions. However, it remains largely unknown whether post-translational modifications could… read more here.
Keywords: acetylation; intrinsically disordered; crebbp; rb1cc1 fip200 ... See more keywords
BMSC-EV-derived lncRNA NORAD Facilitates Migration, Invasion, and Angiogenesis in Osteosarcoma Cells by Regulating CREBBP via Delivery of miR-877-3p
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/8825784
Abstract: Bone marrow mesenchymal stem cells (BMSCs) can boost osteosarcoma (OS) cell proliferation and invasion, yet the function of extracellular vesicles (EVs) derived from BMSCs on OS is scarcely known. This study is aimed at examining… read more here.
Keywords: bmsc; crebbp; mir 877; migration ... See more keywords
Abstract 788: Modeling tumor microenvironmental heterogeneity identifies CREBBP as a novel tumor suppressor in breast cancer
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DOI: 10.1158/1538-7445.am2018-788
Abstract: Solid tumors display significant histological, genetic and micro-environmental intra-tumor heterogeneity that can change substantially over the course of their evolutionary trajectory. In particular, changes in the micro-environmental complexity within breast cancer such as hypoxic and… read more here.
Keywords: crebbp; heterogeneity; breast cancer; cancer ... See more keywords
Abstract 978: In vivo shRNA screening identifies synthetic cytotoxicity in CREBBP/EP300 mutant head and neck cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-978
Abstract: The p300-CBP1 coactivator family members (CREB-binding protein (CREBBP) and E1A binding protein p300 (EP300)) share significant homology and act as transcriptional co-activators for a large number of target genes. These genes are collectively mutated in… read more here.
Keywords: crebbp; ep300; crebbp ep300; hpv ... See more keywords
Abstract 1766: CREBBP, NOTCH2 and GNASmutational profile in uterine sarcomas
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DOI: 10.1158/1538-7445.am2024-1766
Abstract: Background: Uterine sarcomas (US) present clinical challenges due to their dynamic behavior and limited treatment options. Representing 1-3% of uterine cancer cases, these tumors exhibit rapid growth, high recurrence rates, and resistance to the standard… read more here.
Keywords: substitution; crebbp; uterine sarcomas; mutation ... See more keywords
Abstract 363: Genetic or pharmacological inactivation of CREBBP sensitizes B-cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-363
Abstract: B-cell acute lymphoblastic leukemia (B-ALL) is an aggressive hematological malignancy of B lineage progenitors. It remains a leading cause of death in childhood, while outcomes in adults are dismal. There is therefore a need to… read more here.
Keywords: acute lymphoblastic; crebbp; cell; cell acute ... See more keywords
Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-18-0385
Abstract: CREBBP, encoding an acetyltransferase, is among the most frequently mutated genes in small cell lung cancer (SCLC), a deadly neuroendocrine tumor type. We report acceleration of SCLC upon Crebbp inactivation in an autochthonous mouse model.… read more here.
Keywords: crebbp; crebbp loss; cancer; cell ... See more keywords