Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment
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DOI: 10.1038/s41467-024-47012-1
Abstract: Despite regulating overlapping gene enhancers and pathways, CREBBP and KMT2D mutations recurrently co-occur in germinal center (GC) B cell-derived lymphomas, suggesting potential oncogenic cooperation. Herein, we report that combined haploinsufficiency of Crebbp and Kmt2d induces… read more here.
Keywords: crebbp kmt2d; crebbp; cell; lymphomagenesis ... See more keywords