CREM-transgene mice: An animal model of atrial fibrillation and thrombogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis research"
DOI: 10.1016/j.thromres.2017.07.033
Abstract: BACKGROUND The molecular pathomechanisms underlying atrial thrombogenesis are multifactorial and still require detailed investigations. Transgenic mice with cardiomyocyte-directed expression of the transcriptional repressor CREM-IbΔC-X (CREM-TG) represent an experimental model of atrial fibrillation (AF) that shows… read more here.
Keywords: thrombogenesis; model atrial; crem; atrial fibrillation ... See more keywords
Clear cell tumor with melanocytic differentiation and MITF::CREM translocation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cutaneous pathology"
DOI: 10.1111/cup.14427
Abstract: In addition to melanoma, a large and diverse family of tumors shows melanocytic differentiation. The best characterized member of this family is clear cell sarcoma, which is characterized by EWSR1::ATF1 and EWSR1::CREB1 fusions. These fusions… read more here.
Keywords: crem; melanocytic differentiation; clear cell; differentiation ... See more keywords
Characterization of the Genetic Program Linked to the Development of Atrial Fibrillation in CREM-Ib&Dgr;C-X Mice
Sign Up to like & getrecommendations! Published in 2017 at "Circulation: Arrhythmia and Electrophysiology"
DOI: 10.1161/circep.117.005075
Abstract: Background— Reduced expression of genes regulated by the transcription factors CREB/CREM (cAMP response element-binding protein/modulator) is linked to atrial fibrillation (AF) susceptibility in patients. Cardiomyocyte-directed expression of the inhibitory CREM isoform CREM-Ib&Dgr;C-X in transgenic mice… read more here.
Keywords: atrial fibrillation; program linked; crem dgr; mice ... See more keywords
Transcription Factor CREM Mediates High Glucose Response in Cardiomyocytes and in a Male Mouse Model of Prolonged Hyperglycemia
Sign Up to like & getrecommendations! Published in 2017 at "Endocrinology"
DOI: 10.1210/en.2016-1960
Abstract: This study aims at investigating the epigenetic landscape of cardiomyocytes exposed to elevated glucose levels. High glucose (30 mM) for 72 hours determined some epigenetic changes in mouse HL-1 and rat differentiated H9C2 cardiomyocytes including… read more here.
Keywords: high glucose; crem; transcription factor; factor crem ... See more keywords
CREM Is Correlated With Immune-Suppressive Microenvironment and Predicts Poor Prognosis in Gastric Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.697748
Abstract: The transcriptional repressor cAMP response element modulator (CREM) has an important role in T-cell development. In this study, we used the integrated Bioinformatics Methods to explore the role of CREM in gastric adenocarcinoma (GAC). Our… read more here.
Keywords: gac; cell; gastric adenocarcinoma; crem correlated ... See more keywords