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   Articles with "crem" as a keyword



Potential Role of CREM in Diabetes‐Associated Testicular Dysfunction: Current Evidence and Future Perspectives

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recommendations! Published in 2025 at "Reproductive Medicine and Biology"

DOI: 10.1002/rmb2.12661

Abstract: Type 2 diabetes mellitus (T2D) is a growing metabolic disorder affecting all age groups and is linked to testiculopathy, a key contributor to male infertility. Testiculopathy disrupts spermatogenesis and the sperm microenvironment, with the cyclic… read more here.

Keywords: testicular dysfunction; role crem; crem; potential role ... See more keywords

Extra-abdominal and intra-abdominal FET::CREM fusion mesenchymal neoplasms: comparative clinicopathological study of 9 new cases further supporting a distinct potentially aggressive sarcoma and report of novel sites

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recommendations! Published in 2024 at "Virchows Archiv"

DOI: 10.1007/s00428-024-03917-2

Abstract: With the wide use of RNA sequencing technologies, the family of FET::CREB fusion mesenchymal neoplasms has expanded rapidly to include potentially aggressive neoplasms, not fitting any well established WHO entity. Recently, a group of intra-abdominal… read more here.

Keywords: fet; potentially aggressive; fusion mesenchymal; crem ... See more keywords

CREM-transgene mice: An animal model of atrial fibrillation and thrombogenesis.

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recommendations! Published in 2018 at "Thrombosis research"

DOI: 10.1016/j.thromres.2017.07.033

Abstract: BACKGROUND The molecular pathomechanisms underlying atrial thrombogenesis are multifactorial and still require detailed investigations. Transgenic mice with cardiomyocyte-directed expression of the transcriptional repressor CREM-IbΔC-X (CREM-TG) represent an experimental model of atrial fibrillation (AF) that shows… read more here.

Keywords: thrombogenesis; model atrial; crem; atrial fibrillation ... See more keywords

Clear cell tumor with melanocytic differentiation and MITF::CREM translocation.

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recommendations! Published in 2023 at "Journal of cutaneous pathology"

DOI: 10.1111/cup.14427

Abstract: In addition to melanoma, a large and diverse family of tumors shows melanocytic differentiation. The best characterized member of this family is clear cell sarcoma, which is characterized by EWSR1::ATF1 and EWSR1::CREB1 fusions. These fusions… read more here.

Keywords: crem; melanocytic differentiation; clear cell; differentiation ... See more keywords

The cAMP responsive element modulator (CREM) transcription factor influences susceptibility to undernutrition and infection

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recommendations! Published in 2025 at "mBio"

DOI: 10.1128/mbio.01390-25

Abstract: ABSTRACT We previously identified genetic polymorphisms associated with Entamoeba histolytica-positive diarrhea at the locus containing the transcription factor, cAMP responsive element modulator (CREM). Genetic association testing in birth cohorts of Bangladeshi children showed the previously… read more here.

Keywords: transcription factor; element; undernutrition; crem ... See more keywords

Characterization of the Genetic Program Linked to the Development of Atrial Fibrillation in CREM-Ib&Dgr;C-X Mice

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recommendations! Published in 2017 at "Circulation: Arrhythmia and Electrophysiology"

DOI: 10.1161/circep.117.005075

Abstract: Background— Reduced expression of genes regulated by the transcription factors CREB/CREM (cAMP response element-binding protein/modulator) is linked to atrial fibrillation (AF) susceptibility in patients. Cardiomyocyte-directed expression of the inhibitory CREM isoform CREM-Ib&Dgr;C-X in transgenic mice… read more here.

Keywords: atrial fibrillation; program linked; crem dgr; mice ... See more keywords

Transcription Factor CREM Mediates High Glucose Response in Cardiomyocytes and in a Male Mouse Model of Prolonged Hyperglycemia

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recommendations! Published in 2017 at "Endocrinology"

DOI: 10.1210/en.2016-1960

Abstract: This study aims at investigating the epigenetic landscape of cardiomyocytes exposed to elevated glucose levels. High glucose (30 mM) for 72 hours determined some epigenetic changes in mouse HL-1 and rat differentiated H9C2 cardiomyocytes including… read more here.

Keywords: high glucose; crem; transcription factor; factor crem ... See more keywords

CREM Is Correlated With Immune-Suppressive Microenvironment and Predicts Poor Prognosis in Gastric Adenocarcinoma

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recommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2021.697748

Abstract: The transcriptional repressor cAMP response element modulator (CREM) has an important role in T-cell development. In this study, we used the integrated Bioinformatics Methods to explore the role of CREM in gastric adenocarcinoma (GAC). Our… read more here.

Keywords: gac; cell; gastric adenocarcinoma; crem correlated ... See more keywords