Solubilization of vardenafil HCl in lipid-based formulations enhances its oral bioavailability in vivo: A comparative study using Tween - 20 and Cremophor - EL
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2018.12.079
Abstract: Abstract The aim of the present investigation was to develop and characterize a promising oral drug delivery system for vardenafil HCl trihydrate (VDN), a poorly soluble drug. For this, self-microemulsifying drug delivery system (SMEDDS) was… read more here.
Keywords: vardenafil hcl; study using; drug; study ... See more keywords
Cremophor EL Alters the Plasma Protein Binding and Pharmacokinetic Profile of Valspodar in Rats.
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DOI: 10.1055/s-0043-111411
Abstract: Cremophor EL is a nonionic surfactant widely used in pharmaceutical formulations. Nonetheless, there are several reports on the influence of this excipient on the protein binding, pharmacokinetics, and pharmacodynamics of drugs. Valspodar is an investigational… read more here.
Keywords: valspodar; protein binding; plasma protein; formulation ... See more keywords
Formulation and in vivo assessment of terconazole-loaded polymeric mixed micelles enriched with Cremophor EL as dual functioning mediator for augmenting physical stability and skin delivery
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DOI: 10.1080/10717544.2018.1436098
Abstract: Abstract The aim of the current study was to formulate terconazole (TCZ) loaded polymeric mixed micelles (PMMs) incorporating Cremophor EL as a stabilizer and a penetration enhancer. A 23 full factorial design was performed using… read more here.
Keywords: optimal pmms; pmms; delivery; tcz ... See more keywords
Sex-specific and concentration-dependent influence of Cremophor RH 40 on ampicillin absorption via its effect on intestinal membrane transporters in rats
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DOI: 10.1371/journal.pone.0263692
Abstract: Pharmaceutical excipients are the basic materials and important components of pharmaceutical preparations, and play an important role in improving the efficacy of drugs and reducing adverse reactions. Therefore, selecting suitable excipients for dosage form is… read more here.
Keywords: cremophor; effect; influence; membrane transporters ... See more keywords