Co-option of the piRNA pathway to regulate neural crest specification
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn1441
Abstract: Across Metazoa, Piwi proteins play a critical role in protecting the germline genome through piRNA-mediated repression of transposable elements. In vertebrates, activity of Piwi proteins and the piRNA pathway was thought to be gonad specific.… read more here.
Keywords: crest specification; neural crest; pirna pathway;
Dkk2 promotes neural crest specification by activating Wnt/β-catenin signaling in a GSK3β independent manner
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.34404
Abstract: Neural crest progenitors are specified through the modulation of several signaling pathways, among which the activation of Wnt/β-catenin signaling by Wnt8 is especially critical. Glycoproteins of the Dickkopf (Dkk) family are important modulators of Wnt… read more here.
Keywords: catenin signaling; catenin; crest specification; neural crest ... See more keywords