Amino acids at positions 3, 168, and 169 are associated with the ability of Nef proteins from HIV‐1 CRF01_AE to downmodulate CD4
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DOI: 10.1002/jmv.24851
Abstract: Several HIV‐1 subtypes are co‐circulating among various high‐risk groups in China, and an increasing prevalence of CRF01_AE was observed among MSM (men who have sex with men) within recent years. Patients infected with CRF01_AE may… read more here.
Keywords: positions 168; hiv crf01; nef proteins; disease progression ... See more keywords
Evaluation of susceptibility of HIV-1 CRF01_AE variants to neutralization by a panel of broadly neutralizing antibodies
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DOI: 10.1007/s00705-018-4011-7
Abstract: Broadly neutralizing antibodies (bNAbs) are very promising agents for HIV-1 prophylaxis and AIDS treatment. However, the neutralization susceptibility of circulating recombinants such as CRF01_AE, which is becoming increasingly prevalent, has not been studied in detail… read more here.
Keywords: susceptibility; neutralizing antibodies; pg9 pg16; evaluation susceptibility ... See more keywords
Four Closely Related HIV-1 CRF01_AE/CRF07_BC Recombinant Forms Identified in East China.
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DOI: 10.1089/aid.2017.0049
Abstract: Five near full-length genomes of novel second-generation HIV-1 recombinant virus (JS150021, JS150029, JS150129, JS150132, and AH150183) were identified from five HIV-positive people in Jiangsu and Anhui province, east China. Phylogenic analyses showed that these five… read more here.
Keywords: closely related; hiv; recombinant forms; recombinant ... See more keywords
Characterization of a New HIV-1 CRF01_AE/B Recombinant Virus Form Among Men Who Have Sex with Men in Shanghai, China.
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DOI: 10.1089/aid.2018.0197
Abstract: To date, there are 16 types of CRF01_AE/B circulating recombinant forms identified, and most of them are distributed in Asian countries such as China, Malaysia, and Singapore. Previous HIV molecular epidemiological surveys showed that CRF01_AE… read more here.
Keywords: crf01; hiv; sex men; men sex ... See more keywords
Genomic Characterization of a Novel HIV-1 Second-Generation recombinant form (CRF01_AE/B) From a Men Who Have Sex with Men in Guangxi Zhuang Autonomous Region, China.
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DOI: 10.1089/aid.2019.0149
Abstract: We report here a novel HIV-1 recombinant form (18GXD4705) composed of CRF01_AE and subtype B, acquired from an unmarried HIV-positive young-man subject infected through homosexual contact in Guangxi province of eastern China. The phylogenetic analysis… read more here.
Keywords: novel hiv; crf01; recombinant form; region ... See more keywords
Characterization of a New HIV-1 CRF01_AE/B Recombinant Virus Form Among Men Who Have Sex with Men inBaoding, Hebei,China.
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DOI: 10.1089/aid.2021.0209
Abstract: We analyzed the near full-length genome of an HIV-1-positive sample(027A) with an undetermined subtype to determine the recombinant characteristics and possible source of the parental virus. 027A is a novel HIV-1 second-generation recombinant form composed… read more here.
Keywords: new hiv; crf01; form; hiv ... See more keywords
Rapid CD4+ T-cell decline is associated with coreceptor switch among MSM primarily infected with HIV-1 CRF01_AE in Northeast China
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DOI: 10.1097/qad.0000000000001981
Abstract: Objective: CRF01_AE is the most prevalent HIV-1 subtype among MSM in China. However, the characteristics and underlying mechanism of the accelerated CD4+ T-cell decline in CRF01_AE-infected MSM remain incompletely understood. Design: A long-term prospective follow-up… read more here.
Keywords: crf01; coreceptor switch; cell decline; cd4 cell ... See more keywords
P148 Transcontinental dissemination of the major HIV-1 CRF01_AE lineages circulating in china
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DOI: 10.1136/sextrans-2019-sti.313
Abstract: Background While HIV-1 CRF01_AE has caused a large epidemic in Mainland China, and distinct lineages related to transmission among various high-risk populations have been identified, whether its transmissions have dispersal outside remains poorly understood. We… read more here.
Keywords: mainland china; hiv; hiv crf01; crf01 lineages ... See more keywords
The S68G polymorphism is a compensatory mutation associated with the drug resistance mutation K65R in CRF01_AE strains
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DOI: 10.1186/s12879-020-4836-z
Abstract: Background The rate of S68G mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase has increased and is closely related to the K65R mutation among CRF01_AE-infected patients who failed treatment. We aimed to explore… read more here.
Keywords: mutation; k65r; resistance; s68g mutation ... See more keywords
Analysis of temporal changes in HIV-1 CRF01_AE gag genetic variability and CD8 T-cell epitope evolution
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DOI: 10.1371/journal.pone.0267130
Abstract: Currently, little is known about the time-dependent evolution of human immunodeficiency virus-1 (HIV-1) circulating recombinant forms (CRF) 01_AE, a dominant recombinant form associated with HIV-1 epidemics worldwide. Since gag is a highly immunodominant HIV-1 protein,… read more here.
Keywords: variability; crf01; hiv crf01; crf01 gag ... See more keywords
The Molecular Epidemiological and Immunological Characteristics of HIV-1 CRF01_AE/B Recombinants in Nanjing, China
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DOI: 10.3389/fmicb.2022.936502
Abstract: Human immunodeficiency virus-type 1 (HIV-1) CRF01_AE/B recombinants are newly emerging strains that are spreading rapidly in Southern and Eastern China. This study aimed to elucidate the molecular epidemiological characteristics of HIV-1 CRF01_AE/B recombinants in Nanjing… read more here.
Keywords: recombinants nanjing; crf01 recombinants; molecular epidemiological; characteristics hiv ... See more keywords