Amino acids at positions 3, 168, and 169 are associated with the ability of Nef proteins from HIV‐1 CRF01_AE to downmodulate CD4
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DOI: 10.1002/jmv.24851
Abstract: Several HIV‐1 subtypes are co‐circulating among various high‐risk groups in China, and an increasing prevalence of CRF01_AE was observed among MSM (men who have sex with men) within recent years. Patients infected with CRF01_AE may… read more here.
Keywords: positions 168; hiv crf01; nef proteins; disease progression ... See more keywords
Evaluation of susceptibility of HIV-1 CRF01_AE variants to neutralization by a panel of broadly neutralizing antibodies
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DOI: 10.1007/s00705-018-4011-7
Abstract: Broadly neutralizing antibodies (bNAbs) are very promising agents for HIV-1 prophylaxis and AIDS treatment. However, the neutralization susceptibility of circulating recombinants such as CRF01_AE, which is becoming increasingly prevalent, has not been studied in detail… read more here.
Keywords: susceptibility; neutralizing antibodies; pg9 pg16; evaluation susceptibility ... See more keywords
Four Closely Related HIV-1 CRF01_AE/CRF07_BC Recombinant Forms Identified in East China.
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DOI: 10.1089/aid.2017.0049
Abstract: Five near full-length genomes of novel second-generation HIV-1 recombinant virus (JS150021, JS150029, JS150129, JS150132, and AH150183) were identified from five HIV-positive people in Jiangsu and Anhui province, east China. Phylogenic analyses showed that these five… read more here.
Keywords: closely related; hiv; recombinant forms; recombinant ... See more keywords
Characterization of a New HIV-1 CRF01_AE/B Recombinant Virus Form Among Men Who Have Sex with Men in Shanghai, China.
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DOI: 10.1089/aid.2018.0197
Abstract: To date, there are 16 types of CRF01_AE/B circulating recombinant forms identified, and most of them are distributed in Asian countries such as China, Malaysia, and Singapore. Previous HIV molecular epidemiological surveys showed that CRF01_AE… read more here.
Keywords: crf01; hiv; sex men; men sex ... See more keywords
Genomic Characterization of a Novel HIV-1 Second-Generation recombinant form (CRF01_AE/B) From a Men Who Have Sex with Men in Guangxi Zhuang Autonomous Region, China.
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DOI: 10.1089/aid.2019.0149
Abstract: We report here a novel HIV-1 recombinant form (18GXD4705) composed of CRF01_AE and subtype B, acquired from an unmarried HIV-positive young-man subject infected through homosexual contact in Guangxi province of eastern China. The phylogenetic analysis… read more here.
Keywords: novel hiv; crf01; recombinant form; region ... See more keywords
Characterization of a New HIV-1 CRF01_AE/B Recombinant Virus Form Among Men Who Have Sex with Men inBaoding, Hebei,China.
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DOI: 10.1089/aid.2021.0209
Abstract: We analyzed the near full-length genome of an HIV-1-positive sample(027A) with an undetermined subtype to determine the recombinant characteristics and possible source of the parental virus. 027A is a novel HIV-1 second-generation recombinant form composed… read more here.
Keywords: new hiv; crf01; form; hiv ... See more keywords
Near-Full-Length Genomic Characterization of Two Novel HIV-1 Unique Recombinants (CRF01_AE/CRF07_BC) and (CRF01_AE/CRF68_01B) in Shijiazhuang, Hebei Province, China
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DOI: 10.1089/aid.2024.0114
Abstract: Heterosexual transmission (HETE) represents the predominant method of transmission for the human immunodeficiency virus type 1 (HIV-1) in Shijiazhuang, Hebei Province, China. The number of circulating recombinant forms (CRFs) and unique recombinant forms (URFs) continues… read more here.
Keywords: two novel; crf01; hiv; hebei province ... See more keywords
Sequence Notes: Characterization of the Near-Full-Length Genome of Two Novel Unique Recombinant Genome (CRF01_AE/CRF79_0107, CRF01_AE/CRF07_BC) in Hebei, China
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DOI: 10.1089/aid.2024.0127
Abstract: The global fight against human immunodeficiency virus (HIV) is complicated by its extensive genetic diversity, which arises from high mutation rates, rapid replication, and frequent recombination events. These factors lead to the emergence of numerous… read more here.
Keywords: crf01; genome; crf01 crf79; crf01 crf07 ... See more keywords
Rapid CD4+ T-cell decline is associated with coreceptor switch among MSM primarily infected with HIV-1 CRF01_AE in Northeast China
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DOI: 10.1097/qad.0000000000001981
Abstract: Objective: CRF01_AE is the most prevalent HIV-1 subtype among MSM in China. However, the characteristics and underlying mechanism of the accelerated CD4+ T-cell decline in CRF01_AE-infected MSM remain incompletely understood. Design: A long-term prospective follow-up… read more here.
Keywords: crf01; coreceptor switch; cell decline; cd4 cell ... See more keywords
Epidemiological Links of HIV-1 CRF01_AE among Men Who Have Sex with Men in Northern Vietnam and Japan.
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DOI: 10.1097/qad.0000000000004406
Abstract: OBJECTIVES The bidirectional increase of visitors between Vietnam and Japan has raised concerns about the spread of CRF01_AE; however, the epidemiological characteristics of CRF01_AE in Vietnam and its relationship with Japan remain unclear. We compared… read more here.
Keywords: crf01; men sex; northern vietnam; vietnam japan ... See more keywords
P148 Transcontinental dissemination of the major HIV-1 CRF01_AE lineages circulating in china
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DOI: 10.1136/sextrans-2019-sti.313
Abstract: Background While HIV-1 CRF01_AE has caused a large epidemic in Mainland China, and distinct lineages related to transmission among various high-risk populations have been identified, whether its transmissions have dispersal outside remains poorly understood. We… read more here.
Keywords: mainland china; hiv; hiv crf01; crf01 lineages ... See more keywords