Don’t stress about CRF: assessing the translational failures of CRF1antagonists
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4556-2
Abstract: BackgroundDr. Athina Markou sought treatments for a common neural substrate shared by depression and drug dependence. Antagonists of corticotropin-releasing factor (CRF) receptors, a target of interest to her, have not reached the clinic despite strong… read more here.
Keywords: crf1; crf assessing; assessing translational; crf1 antagonists ... See more keywords
The center of the emotional universe: Alcohol, stress, and CRF1 amygdala circuitry.
Sign Up to like & getrecommendations! Published in 2018 at "Alcohol"
DOI: 10.1016/j.alcohol.2018.03.009
Abstract: The commonalities between different phases of stress and alcohol use as well as the high comorbidity between alcohol use disorders (AUDs) and anxiety disorders suggest common underlying cellular mechanisms governing the rewarding and aversive aspects… read more here.
Keywords: alcohol stress; crf1; stress; center ... See more keywords
Insular cortex corticotropin-releasing factor integrates stress signaling with social affective behavior
Sign Up to like & getrecommendations! Published in 2022 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-022-01292-7
Abstract: Impairments in identifying and responding to the emotions of others manifest in a variety of psychopathologies. Therefore, elaborating the neurobiological mechanisms that underpin social responses to social emotions, or social affective behavior, is a translationally… read more here.
Keywords: crf1; insular cortex; social affective; affective behavior ... See more keywords