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   Articles with "crgd" as a keyword



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AZD9291 Resistance Reversal Activity of a pH‐Sensitive Nanocarrier Dual‐Loaded with Chloroquine and FGFR1 Inhibitor in NSCLC

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recommendations! Published in 2021 at "Advanced Science"

DOI: 10.1002/advs.202002922

Abstract: Abstract AZD9291 can effectively prolong survival of non‐small cell lung cancer (NSCLC) patients. Unfortunately, the mechanism of its acquired drug resistance is largely unknown. This study shows that autophagy and fibroblast growth factor receptor 1… read more here.

Keywords: azd9291; resistance reversal; crgd; resistance ... See more keywords
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Multifunctional tumor-targeted PLGA nanoparticles delivering Pt(IV)/siBIRC5 for US/MRI imaging and overcoming ovarian cancer resistance.

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recommendations! Published in 2020 at "Biomaterials"

DOI: 10.1016/j.biomaterials.2020.120478

Abstract: Cisplatin (Pt(II)) resistance is an important factor in the high mortality rates of ovarian cancer. Herein, we synthesized multifunctional tumor-targeted poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs-cRGD) for monitoring therapeutic effects by dual-mode imaging and overcoming cisplatin… read more here.

Keywords: nps crgd; crgd; resistance; ovarian cancer ... See more keywords
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Efficient synthesis of cRGD functionalized polymers as building blocks of targeted drug delivery systems

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recommendations! Published in 2018 at "European Polymer Journal"

DOI: 10.1016/j.eurpolymj.2018.04.025

Abstract: Abstract Synthetic peptides with cyclic arginine-glycine-aspartate motif (cRGD) play an important role in cell recognition and cell adhesion. cRGD-decorated soluble polymers and polymeric nanoparticles have been increasingly used for cell-specific delivery of antitumor drugs. While… read more here.

Keywords: blocks targeted; building blocks; delivery; synthesis crgd ... See more keywords
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cRGD‐decorated biodegradable polytyrosine nanoparticles for robust encapsulation and targeted delivery of doxorubicin to colorectal cancer in vivo

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recommendations! Published in 2019 at "Journal of Controlled Release"

DOI: 10.1016/j.jconrel.2019.03.005

Abstract: ABSTRACT The clinical success of nanomedicines demands on the development of simple biodegradable nanocarriers that can efficiently and stably encapsulate chemotherapeutics while quickly release the payloads into target cancer cells. Herein, we report that cRGD‐decorated… read more here.

Keywords: crgd; dox; crgd ptn; cancer ... See more keywords
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A novel amphiphilic fluorescent probe BODIPY–O-CMC–cRGD as a biomarker and nanoparticle vector

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recommendations! Published in 2018 at "RSC Advances"

DOI: 10.1039/c8ra02125b

Abstract: Fluorescent probes have been demonstrated to be promising candidates as biomarkers and biological carriers. Our study focuses on the development of a novel amphiphilic fluorescent probe with good photostability, high water solubility, excellent specificity and… read more here.

Keywords: fluorescent probe; probe; amphiphilic fluorescent; crgd ... See more keywords
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cRGD-modified and disulfide bond-crosslinked polymer nanoparticles based on iopamidol as a tumor-targeted CT contrast agent

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recommendations! Published in 2020 at "Polymer Chemistry"

DOI: 10.1039/c9py01418g

Abstract: Among all X-ray tumor diagnostic imaging modalities, computed tomography (CT) has been most commonly used owing to its high spatial resolution and high detection efficiency. In order to achieve enhanced CT imaging on tumors, methacrylated… read more here.

Keywords: disulfide bond; contrast; crgd; polymer nanoparticles ... See more keywords
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Reductive nanocomplex encapsulation of cRGD-siRNA conjugates for enhanced targeting to cancer cells

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recommendations! Published in 2017 at "International Journal of Nanomedicine"

DOI: 10.2147/ijn.s136726

Abstract: In this study, through covalent conjugation and lipid material entrapment, a combined modification strategy was established for effective delivery of small interfering RNA (siRNA). Single strands of siRNA targeting to BRAFV600E gene (siMB3) conjugated with… read more here.

Keywords: sirna conjugates; bis crgd; crgd sirna; crgd ... See more keywords
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Cyclic RGD-Decorated Liposomal Gossypol AT-101 Targeting for Enhanced Antitumor Effect

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recommendations! Published in 2022 at "International Journal of Nanomedicine"

DOI: 10.2147/ijn.s341824

Abstract: Introduction (-)-Gossypol (AT-101), the (-)-enantiomer of the natural compound gossypol, has shown significant inhibitory effects on various types of cancers such as osteosarcoma, myeloma, glioma, lung cancer, and prostate cancer. However, the clinical application of… read more here.

Keywords: effect; crgd; antitumor effect; gos crgd ... See more keywords
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Preparation of DSPE-PEG-cRGD Modified Cationic Liposomes for Delivery of OC-2 shRNA and The Antitumor Effects on Breast Cancer

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recommendations! Published in 2022 at "Pharmaceutics"

DOI: 10.3390/pharmaceutics14102157

Abstract: Cationic liposome delivery of interfering RNA (shRNA) plays an important role in tumor therapy. The cyclic Arg-Gly-Asp (cRGD) modified cationic liposomes (cRGD-CL) were designed for targeted delivery of ONECUT2 (OC-2) shRNA (pshOC-2) to breast cancer… read more here.

Keywords: shrna; crgd; breast cancer; crgd modified ... See more keywords