CRH promotes human colon cancer cell proliferation via IL‐6/JAK2/STAT3 signaling pathway and VEGF‐induced tumor angiogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22691
Abstract: Corticotrophin‐releasing hormone (CRH) has been demonstrated to participate in various diseases. Our previous study showed that its receptor CRHR1 mediated the development of colitis‐associated cancer in mouse model. However, the detailed mechanisms remain unclear. In… read more here.
Keywords: cancer; cell proliferation; crh; colon cancer ... See more keywords
Targeted overexpression of CRH receptor subtype 1 in central amygdala neurons: effect on alcohol-seeking behavior
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-4908-6
Abstract: RationaleThe corticotropin-releasing hormone (CRH) system is a key mediator of stress-induced responses in alcohol-seeking behavior. Recent research has identified the central nucleus of the amygdala (CeA), a brain region involved in the regulation of fear… read more here.
Keywords: cea; crhr1; effect; crh ... See more keywords
Endometrial CRH and implantation: from bench to bedside
Sign Up to like & getrecommendations! Published in 2018 at "Hormones"
DOI: 10.1007/s42000-018-0042-4
Abstract: Endometrial corticotropin-releasing hormone (CRH) has been described as a mediator of decidualisation and as a contributor of maternal–fetal immunotolerance. Deregulation of the CRH expression pattern has been associated with unfavourable reproductive outcomes as well as… read more here.
Keywords: endometrial crh; implantation bench; crh; bench bedside ... See more keywords
CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.09.037
Abstract: Local cues in the adult neurogenic niches dynamically regulate homeostasis in neural stem cells, whereas their identity and associated molecular mechanisms remain poorly understood. Here, we show that corticotropin-releasing hormone (CRH), the major mediator of… read more here.
Keywords: crh promotes; crh; stem cells; activity ... See more keywords
Inferior petrosal sinus sampling and stimulation with CRH: 15 years of experience in a tertiary hospital.
Sign Up to like & getrecommendations! Published in 2021 at "Endocrinologia, diabetes y nutricion"
DOI: 10.1016/j.endinu.2020.10.013
Abstract: BACKGROUND Inferior petrosal sinus sampling (IPSS) is indicated in the diagnosis of adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome (CS), especially when the results of the initial diagnostic tests are discordant. OBJECTIVE To describe the patients who… read more here.
Keywords: stimulation; sinus sampling; crh; tertiary hospital ... See more keywords
Prenatal betamethasone exposure increases corticotropin-releasing hormone expression along with increased hippocampal slice excitability in the developing hippocampus
Sign Up to like & getrecommendations! Published in 2020 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2020.106276
Abstract: BACKGROUND The objective of this study was to determine whether prenatal exposure to betamethasone alters hippocampal expression of corticotropin-releasing hormone (CRH) and resultant hippocampal circuit excitability. METHODS Real time (RT)-PCR and western blots were used… read more here.
Keywords: corticotropin releasing; exposure; betamethasone; crh ... See more keywords
Thyrotropic activity of corticotropin-releasing hormone in an altricial bird species, the zebra finch (Taeniopygia guttata).
Sign Up to like & getrecommendations! Published in 2018 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2017.10.012
Abstract: In chicken, corticotropin-releasing hormone (CRH) acts as a thyrotropin (TSH)-releasing factor, mediated by the type 2 CRH receptor (CRHR2) on the thyrotropes of the pituitary gland. It is not known whether CRH also controls TSH… read more here.
Keywords: hormone; zebra finch; corticotropin releasing; crh ... See more keywords
Functional diversity of corticotropin-releasing hormone
Sign Up to like & getrecommendations! Published in 2022 at "Nature Reviews Endocrinology"
DOI: 10.1038/s41574-022-00663-w
Abstract: 0123456789();: In 1978, Wylie Vale and colleagues isolated corticotropin-releasing hormone (CRH) from sheep hypothalami and published a study of the modulation of stress-induced adrenocorticotropic hormone (ACTH) release by CRH. The study suggested that endogenous CRH… read more here.
Keywords: releasing hormone; functional diversity; crh; diversity corticotropin ... See more keywords
Social transmission and buffering of synaptic changes after stress
Sign Up to like & getrecommendations! Published in 2017 at "Nature Neuroscience"
DOI: 10.1038/s41593-017-0044-6
Abstract: Stress can trigger enduring changes in neural circuits and synapses. The behavioral and hormonal consequences of stress can also be transmitted to others, but whether this transmitted stress has similar effects on synapses is not… read more here.
Keywords: authentic stress; transmission; crh neurons; transmitted stress ... See more keywords
Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety
Sign Up to like & getrecommendations! Published in 2018 at "Nature Neuroscience"
DOI: 10.1038/s41593-018-0151-z
Abstract: The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH–dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting… read more here.
Keywords: neurons extended; gabaergic long; dopamine release; extended amygdala ... See more keywords
Sensitivity of Different ACTH and Cortisol Concentration Values in Corticotropin-Releasing Hormone Based Tests in Cushing’s Disease
Sign Up to like & getrecommendations! Published in 2023 at "Endocrine Research"
DOI: 10.1080/07435800.2023.2176869
Abstract: ABSTRACT Purpose In Cushing’s disease (CD) patients, the aim of the present study is to confirm sensitivity of several ACTH and cortisol concentration values in different time points, during corticotropin-releasing hormone (CRH) stimulation test and… read more here.
Keywords: sensitivity; crh; cortisol; acth cortisol ... See more keywords