CRIF1-CDK2 Interface Inhibitors: An Unprecedented Strategy for Modulation of Cell Radiosensitivity.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b10207
Abstract: Cyclin-dependent kinases (CDKs) are historic therapeutic targets implicated in tumorigenic events due to their critical involvement in the cell cycle phase. However, selectivity has proven to be a bottleneck, causing repeated failures. Previously, we reported… read more here.
Keywords: cell; crif1 cdk2; interface inhibitors; crif1 ... See more keywords
CR6-interacting factor 1 deficiency reduces endothelial nitric oxide synthase activity by inhibiting biosynthesis of tetrahydrobiopterin
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DOI: 10.1038/s41598-020-57673-9
Abstract: Downregulation of CR6 interacting factor 1 (CRIF1) has been reported to induce mitochondrial dysfunction, resulting in reduced activity of endothelial nitric oxide synthase (eNOS) and NO production in endothelial cells. Tetrahydrobiopterin (BH4) is an important… read more here.
Keywords: biosynthesis; endothelial nitric; crif1; cr6 interacting ... See more keywords
CR6-interacting factor-1 contributes to osteoclastogenesis by inducing receptor activator of nuclear factor κB ligand after radiation.
Sign Up to like & getrecommendations! Published in 2020 at "World journal of stem cells"
DOI: 10.4252/wjsc.v12.i3.222
Abstract: BACKGROUND Radiation induces rapid bone loss and enhances bone resorption and adipogenesis, leading to an increased risk of bone fracture. There is still a lack of effective preventive or therapeutic method for irradiation-induced bone injury.… read more here.
Keywords: receptor activator; activator nuclear; crif1; factor ... See more keywords