CRIF1-CDK2 Interface Inhibitors: An Unprecedented Strategy for Modulation of Cell Radiosensitivity.
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DOI: 10.1021/jacs.8b10207
Abstract: Cyclin-dependent kinases (CDKs) are historic therapeutic targets implicated in tumorigenic events due to their critical involvement in the cell cycle phase. However, selectivity has proven to be a bottleneck, causing repeated failures. Previously, we reported… read more here.
Keywords: cell; crif1 cdk2; interface inhibitors; crif1 ... See more keywords