Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT
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DOI: 10.1186/s12967-020-02416-7
Abstract: NUDT15 and TPMT variants are strong genetic determinants of thiopurine-induced hematological toxicity that results in therapeutic failure in pediatric acute lymphoblastic leukemia (ALL). However, many patients with both wild-type (WT) NUDT15 and TPMT still suffer… read more here.
Keywords: variant; thiopurine induced; nudt15 tpmt; tpmt ... See more keywords
Relationship of CRIM1 and epithelial-mesenchymal transition in hepatocellular carcinoma
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DOI: 10.3760/cma.j.issn.1673-4203.2019.02.012
Abstract: Objective To study the expression and the clinical significance of cysteine rich transmembrane BMP regulator 1(CRIM1) in hepatocellular carcinoma(HCC) and discuss the association between CRIM1 and epithelial-mesenchymal transition(EMT). Methods The cases were came from the… read more here.
Keywords: expression; hcc; epithelial mesenchymal; expression crim1 ... See more keywords