Cripto stabilizes GRP78 on the cell membrane
Sign Up to like & getrecommendations! Published in 2018 at "Protein Science"
DOI: 10.1002/pro.3358
Abstract: The ER resident chaperone molecule GRP78 has been shown to translocate to the cell surface where it associates with Cripto and signals cell growth, playing a still partially understood role in tumorigenesis. Consequently, a better… read more here.
Keywords: cripto stabilizes; stabilizes grp78; cripto; cell ... See more keywords
Identification of myosin II as a cripto binding protein and regulator of cripto function in stem cells and tissue regeneration.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.12.059
Abstract: Cripto regulates stem cell function in normal and disease contexts via TGFbeta/activin/nodal, PI3K/Akt, MAPK and Wnt signaling. Still, the molecular mechanisms that govern these pleiotropic functions of Cripto remain poorly understood. We performed an unbiased… read more here.
Keywords: myosin; regeneration; cripto; function ... See more keywords
CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.87
Abstract: CRIPTO (CR-1, TDGF1) is a cell surface/secreted oncoprotein actively involved in development and cancer. Here, we report that high expression of CRIPTO correlates with poor survival in stratified risk groups of prostate cancer (PCa) patients.… read more here.
Keywords: cripto signaling; cripto grp78; prostate cancer; cripto ... See more keywords
The Function and Prognostic Significance of Cripto-1 in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Investigation"
DOI: 10.1080/07357907.2020.1741604
Abstract: Abstract Cripto-1 is a plasma membrane protein which is not expressed in adult tissue, but some tumors are accompanied by re-activation. We studied the clinical and biological significance of Cripto-1 in colorectal cancer. Cripto-1 was… read more here.
Keywords: colorectal cancer; significance cripto; cripto; cancer ... See more keywords
Abstract 22: A new transgenic mouse model to explore the role of Cripto signaling in lethal prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-22
Abstract: Introduction: Prostate cancer (PCa) at its early stages is treated with surgery or androgen-deprivation therapy, but PCa can turn castration resistant possibly due to pre-existing stem cell-like cells that reinitiate tumor growth and lead to… read more here.
Keywords: role; prostate; cripto; lsl yfp ... See more keywords
Abstract A044: Generation of a new mouse model to study the role of oncofetal Cripto in aggressive lethal prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-a044
Abstract: Introduction: Early stages of prostate cancer (PCa) are commonly treated with surgery and androgen-deprivation therapy, but PCa can turn castration resistant due to pre-existing stem cell-like cells which might re-initiate tumor growth and lead to… read more here.
Keywords: prostate cancer; role; cripto; lsl yfp ... See more keywords
Cripto shapes macrophage plasticity and restricts EndMT in injured and diseased skeletal muscle
Sign Up to like & getrecommendations! Published in 2020 at "EMBO Reports"
DOI: 10.15252/embr.201949075
Abstract: Macrophages are characterized by a high plasticity in response to changes in tissue microenvironment, which allows them to acquire different phenotypes and to exert essential functions in complex processes, such as tissue regeneration. Here, we… read more here.
Keywords: skeletal muscle; muscle; macrophage plasticity; cripto ... See more keywords
Maternal Serum Cripto-1 Levels in Pregnancies Complicated with Placenta Previa and Placenta Accreta Spectrum (PAS).
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the College of Physicians and Surgeons--Pakistan : JCPSP"
DOI: 10.29271/jcpsp.2022.12.1570
Abstract: OBJECTIVE To examine maternal serum Cripto-1 levels in placenta accreta spectrum (PAS) pregnancies and compare them with placenta previa (PP) cases and healthy pregnancies. STUDY DESIGN A prospective case-control study. PLACE AND DURATION OF STUDY… read more here.
Keywords: pas; serum; maternal serum; cripto ... See more keywords
Exosomal Cripto-1 Serves as a Potential Biomarker for Perihilar Cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.730615
Abstract: Perihilar cholangiocarcinoma (PHCCA) has a poor prognosis, mainly due to diagnosis at an advanced stage. Cripto-1 functions as an oncogene and is highly expressed in several human cancers, however, its clinical application in PHCCA is… read more here.
Keywords: exosomal cripto; biomarker; perihilar cholangiocarcinoma; cripto ... See more keywords
Expression of Cripto-1 in the placenta and its role in placenta accreta and placenta previa.
Sign Up to like & getrecommendations! Published in 2019 at "Ginekologia polska"
DOI: 10.5603/gp.2019.0015
Abstract: OBJECTIVES This study Aims to explore the role of placental Cripto-1 in the incidence of an adherent placenta. MATERIAL AND METHODS Ten pregnant women with placenta increta, 20 pregnant women with placenta previa and 30… read more here.
Keywords: cripto placenta; placental cripto; placenta previa; cripto ... See more keywords