In vivo screens using a selective CRISPR antigen removal lentiviral vector system reveal immune dependencies in renal cell carcinoma.
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DOI: 10.1016/j.immuni.2021.01.001
Abstract: CRISPR-Cas9 genome engineering has increased the pace of discovery for immunology and cancer biology, revealing potential therapeutic targets and providing insight into mechanisms underlying resistance to immunotherapy. However, endogenous immune recognition of Cas9 has limited… read more here.
Keywords: system; crispr; antigen; crispr antigen ... See more keywords