CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells
Sign Up to like & getrecommendations! Published in 2020 at "Nature biotechnology"
DOI: 10.1038/s41587-020-0609-x
Abstract: CRISPR-guided DNA cytosine and adenine base editors are widely used for many applications 1 – 4 but primarily create DNA base transitions (that is, pyrimidine-to-pyrimidine or purine-to-purine). Here we describe the engineering of two base… read more here.
Keywords: editors inducing; inducing targeted; base editors; crispr base ... See more keywords
CRISPR base editing applications for identifying cancer-driving mutations
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DOI: 10.1042/bst20200550
Abstract: CRISPR base editing technology is a promising genome editing tool as (i) it does not require a DNA template to introduce mutations and (ii) it avoids creating DNA double-strand breaks, which can lead to unintended… read more here.
Keywords: cancer driving; dna; crispr base; base ... See more keywords
Efficacy and Safety of an Investigational Single-Course CRISPR Base-Editing Therapy Targeting PCSK9 in Nonhuman Primate and Mouse Models
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DOI: 10.1161/circulationaha.122.062132
Abstract: Background: VERVE-101 is an investigational in vivo CRISPR base-editing medicine designed to alter a single DNA base in the PCSK9 gene, permanently turn off hepatic protein production, and thereby durably lower low-density lipoprotein cholesterol. We… read more here.
Keywords: verve; verve 101; pcsk9; crispr base ... See more keywords
Potential CRISPR Base Editing Therapeutic Options in a Sorsby Fundus Dystrophy Patient
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DOI: 10.3390/genes13112103
Abstract: TIMP3 mutations are associated with early-onset macular choroidal neovascularisation for which no treatment currently exists. CRISPR base editing, with its ability to irreversibly correct point mutations by chemical modification of nucleobases at DNA level, may… read more here.
Keywords: sorsby fundus; crispr base; fundus dystrophy; base editing ... See more keywords