CRISPR Inhibition of Essential Peptidoglycan Biosynthesis Genes in Mycobacterium abscessus and Its Impact on β-Lactam Susceptibility
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DOI: 10.1128/aac.00093-22
Abstract: We utilized a CRISPR interference (CRISPRi) assay to control the gene expressions of two predicted essential peptidoglycan biosynthesis genes, pbpB and cwIM, in Mycobacterium abscessus and to evaluate their contribution to β-lactam susceptibility. Our results… read more here.
Keywords: crispr inhibition; biosynthesis genes; mycobacterium abscessus; essential peptidoglycan ... See more keywords