Genomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2118126119
Abstract: Significance A potential outbreak of swine acute diarrhea syndrome coronavirus (SADS-CoV) in the human population could be devastating. Using genomewide CRISPR knockout screening, we identified the placenta-associated 8 protein (PLAC8) as an essential host factor… read more here.
Keywords: plac8 essential; crispr knockout; infection; factor sads ... See more keywords
Abstract 251: Identification of therapeutic vulnerabilities by genome-wide CRISPR knockout library screening of colon cancer organoids
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-251
Abstract: The promise of precision medicine is based on the idea that genetic alterations present only in tumor cells create vulnerabilities that can be targeted for therapeutic intent. In some instances, somatically mutated driver genes such… read more here.
Keywords: crispr knockout; genome wide; colon cancer; wide crispr ... See more keywords
Abstract 5243: CRISPR knockout: How to get high biallelic knockout
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DOI: 10.1158/1538-7445.sabcs18-5243
Abstract: Although homology directed repair (HDR)-mediated gene knockout / knockin is well established, it cannot necessarily be applied in some cell types and organisms with low HDR frequencies. Herein we describe an improved technology for genome-wide… read more here.
Keywords: crispr knockout; crispr; knockout knockin; knockout get ... See more keywords