Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells
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DOI: 10.1371/journal.pgen.1010680
Abstract: Genome-wide association studies have identified >250 genetic variants associated with coronary artery disease (CAD), but the causal variants, genes and molecular mechanisms remain unknown at most loci. We performed pooled CRISPR screens to test the… read more here.
Keywords: associated coronary; endothelial cells; crispr perturbations; artery disease ... See more keywords