Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.03.012
Abstract: Genetic conflict between viruses and their hosts drives evolution and genetic innovation. Prokaryotes evolved CRISPR-mediated adaptive immune systems for protection from viral infection, and viruses have evolved diverse anti-CRISPR (Acr) proteins that subvert these immune… read more here.
Keywords: surveillance complex; crispr rna; guided surveillance; structure ... See more keywords
Therapeutic applications of CRISPR RNA-guided genome editing.
Sign Up to like & getrecommendations! Published in 2017 at "Briefings in functional genomics"
DOI: 10.1093/bfgp/elw032
Abstract: The rapid development of programmable nuclease-based genome editing technologies has enabled targeted gene disruption and correction both in vitro and in vivo This revolution opens up the possibility of precise genome editing at target genomic… read more here.
Keywords: genome editing; crispr rna; therapeutic applications; rna guided ... See more keywords
Anti-CRISPR RNA?
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.361.6408.1212-f
Abstract: Bacterial Immunity Bacteria use the CRISPR-Cas immune system to fend off viruses; viruses use anti-CRISPR proteins to fight back. Some bacteria have acquired anti-CRISPR proteins in their genomes to avoid self-cutting. Meeske and Marraffini report… read more here.
Keywords: crispr cas; crispr rna; crispr; anti crispr ... See more keywords