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   Articles with "crispra" as a keyword



Transcriptional modulation of AREB-1 by CRISPRa improves plant physiological performance under severe water deficit

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-72464-y

Abstract: Plants are sessile organisms, which are vulnerable to environmental stresses. As such, plants have developed multiple molecular, physiological, and cellular mechanisms to cope with natural stressors. However, these environmental adversities, including drought, are sources of… read more here.

Keywords: severe water; plant; water; water deficit ... See more keywords

High throughput CRISPRi and CRISPRa technologies in 3D genome regulation for neuropsychiatric diseases.

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recommendations! Published in 2022 at "Human molecular genetics"

DOI: 10.1093/hmg/ddac193

Abstract: Advances in genomics have led to the identification of many risk loci with hundreds of genes and thousands of DNA variants associated with neuropsychiatric disorders. A significant barrier to understanding the genetic underpinnings of complex… read more here.

Keywords: neuropsychiatric diseases; crispra; high throughput; crispri crispra ... See more keywords

CRISPRactivation-SMS, a message for PAM sequence independent gene up-regulation in Escherichia coli

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac804

Abstract: Abstract Governance of the endogenous gene regulatory network enables the navigation of cells towards beneficial traits for recombinant protein production. CRISPRactivation and interference provides the basis for gene expression modulation but is primarily applied in… read more here.

Keywords: escherichia coli; crispra; pam sequence; regulation ... See more keywords

Dual-mode CRISPRa/i for genome-scale metabolic rewiring in Escherichia coli

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recommendations! Published in 2025 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaf818

Abstract: Abstract CRISPR (clustered regularly interspaced palindromic repeats)-mediated transcriptional regulation is a powerful and programmable approach for controlling gene expression. While CRISPR-based gene repression is well established in bacteria, simultaneous activation and repression remain challenging due… read more here.

Keywords: escherichia coli; system; dual mode; activation ... See more keywords

CRISPRa corrects haploinsufficient obesity

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recommendations! Published in 2019 at "Science"

DOI: 10.1126/science.363.6424.241-l

Abstract: Gene Therapy Loss-of-function mutation in one gene copy, termed haploinsufficiency, can lead to insufficient protein levels and result in human disease. Matharu et al. tested whether a CRISPR-based activation system (CRISPRa) could rescue a haploinsufficient… read more here.

Keywords: science; haploinsufficient obesity; corrects haploinsufficient; obesity ... See more keywords

Abstract 4368964: LncRNA Regulated by Triiodothyronine Confers Cardioprotection in High-Fat-Diet-Induced Atherosclerosis-Driven Myocardial Infarction

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recommendations! Published in 2025 at "Circulation"

DOI: 10.1161/circ.152.suppl_3.4368964

Abstract: Hypothyroidism (HypoTH) is an independent and major risk factor for myocardial infarction (MI). However, long noncoding RNA (lncRNA; ncRNAs>200 bp) mechanisms in the cardiac thyroid hormone (TH) pathway are unclear. An array of in vitro,… read more here.

Keywords: xrik; diet; diet induced; crispra ... See more keywords

Promoting CRISPRa for Targeted Treatment of Epilepsy

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recommendations! Published in 2020 at "Epilepsy Currents"

DOI: 10.1177/1535759720935825

Abstract: In Vivo CRISPRa Decreases Seizures and Rescues Cognitive Deficits in a Rodent Model of Epilepsy Colasante G, Qiu Y, Massimino L, et al. Brain. 2020;143(3):891-905. doi:10.1093/brain/awaa045 Epilepsy is a major health burden, calling for new… read more here.

Keywords: epilepsy; promoting crispra; crispra targeted; crispra ... See more keywords

Comparative analysis of dCas9-VP64 variants and multiplexed guide RNAs mediating CRISPR activation

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recommendations! Published in 2022 at "PLoS ONE"

DOI: 10.1371/journal.pone.0270008

Abstract: CRISPR/Cas9-mediated transcriptional activation (CRISPRa) is a powerful tool for investigating complex biological phenomena. Although CRISPRa approaches based on the VP64 transcriptional activator have been widely studied in both cultured cells and in animal models and… read more here.

Keywords: dcas9 vp64; activation; crispra; dcas9 ... See more keywords

CRISPR/dCas12a-mediated activation of SlPAL2 enhances tomato resistance against bacterial canker disease

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recommendations! Published in 2025 at "PLOS One"

DOI: 10.1371/journal.pone.0320436

Abstract: Crop protection is essential for maintaining and improving agricultural productivity. While pesticides are commonly used to control pests, they pose several challenges, including environmental harm and health risks. Alternative strategies to pesticides include breeding resistant… read more here.

Keywords: resistance; dcas12a; activation; crop ... See more keywords

Clearing of Foreign Episomal DNA from Human Cells by CRISPRa-Mediated Activation of Cytidine Deaminases

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recommendations! Published in 2020 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms21186865

Abstract: Restriction of foreign DNA is a fundamental defense mechanism required for maintaining genomic stability and proper function of mammalian cells. APOBEC cytidine deaminases are crucial effector molecules involved in clearing pathogenic DNA of viruses and… read more here.

Keywords: crispra mediated; dna; crispra; cytidine deaminases ... See more keywords