Microbial CRISPRi and CRISPRa Systems for Metabolic Engineering
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioprocess Engineering"
DOI: 10.1007/s12257-019-0107-5
Abstract: Transcriptional regulation is essential for maintaining the natural cell metabolism of microbes and therefore important for metabolic engineering. The development of non-native transcriptional regulation tools in engineered microbes may change the gene expression and metabolic… read more here.
Keywords: engineering; metabolic engineering; engineering microbial; microbial crispri ... See more keywords
High throughput CRISPRi and CRISPRa technologies in 3D genome regulation for neuropsychiatric diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac193
Abstract: Advances in genomics have led to the identification of many risk loci with hundreds of genes and thousands of DNA variants associated with neuropsychiatric disorders. A significant barrier to understanding the genetic underpinnings of complex… read more here.
Keywords: neuropsychiatric diseases; crispra; high throughput; crispri crispra ... See more keywords
Abstract A186: Dual CRISPRi and CRISPRa screening reveals phenotypic switches in response to BRAF inhibition
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-a186
Abstract: Functional genomic screening with CRISPR-Cas9 has provided a powerful and precise new way to interrogate the phenotypic consequences of gene manipulation in high-throughput, unbiased analyses. Rapid development of pooled lentivirus and deep-sequencing-led approaches has allowed… read more here.
Keywords: gene; dual crispri; crispri crispra; response ... See more keywords