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Published in 2019 at "Biotechnology and Bioprocess Engineering"
DOI: 10.1007/s12257-019-0107-5
Abstract: Transcriptional regulation is essential for maintaining the natural cell metabolism of microbes and therefore important for metabolic engineering. The development of non-native transcriptional regulation tools in engineered microbes may change the gene expression and metabolic…
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Keywords:
engineering;
metabolic engineering;
engineering microbial;
microbial crispri ... See more keywords
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Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac193
Abstract: Advances in genomics have led to the identification of many risk loci with hundreds of genes and thousands of DNA variants associated with neuropsychiatric disorders. A significant barrier to understanding the genetic underpinnings of complex…
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Keywords:
neuropsychiatric diseases;
crispra;
high throughput;
crispri crispra ... See more keywords
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Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-a186
Abstract: Functional genomic screening with CRISPR-Cas9 has provided a powerful and precise new way to interrogate the phenotypic consequences of gene manipulation in high-throughput, unbiased analyses. Rapid development of pooled lentivirus and deep-sequencing-led approaches has allowed…
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Keywords:
gene;
dual crispri;
crispri crispra;
response ... See more keywords