A primordial germ cell-like-cell platform enables CRISPRi screen for epigenetic fertility modifiers
Sign Up to like & getrecommendations! Published in 2025 at "EMBO Reports"
DOI: 10.1038/s44319-025-00633-z
Abstract: Primordial germ cells (PGCs) are the precursors of gametes, and the ability to derive PGC-like cells (PGCLCs) from pluripotent stem cells has transformed germline research. A key limitation remains producing PGCLCs in sufficient numbers for… read more here.
Keywords: platform enables; pgclcs; like cells; crispri screen ... See more keywords
Abstract 6154: Targeted CRISPRi screen identifies functional variants and novel target genes at multiple renal cell carcinoma (RCC) susceptibility loci
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-6154
Abstract: Genome-wide association studies (GWAS) have identified 13 renal cell carcinoma (RCC) risk regions, as well as 7 regions with nominal significance, but detailed investigation of how these regions function is required to reveal the underlying… read more here.
Keywords: rcc susceptibility; crispri screen; target genes; rcc ... See more keywords
Abstract Tu0067: A Genome-wide CRISPRi Screen Implicates Coronary Artery Disease GWAS Genes as Key Regulators of Adventitial Fibroblast Proliferation
Sign Up to like & getrecommendations! Published in 2025 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atv.45.suppl_1.tu0067
Abstract: Background: Vascular diseases, including atherosclerosis and aneurysms, are the leading causes of death in the US and world-wide. Spatial transcriptomics alongside lineage-tracing and lineage-ablation data implicates critical roles for adventitial fibroblasts (AdvFibs) in both atherosclerosis… read more here.
Keywords: advfib activation; crispri screen; genome wide; activation ... See more keywords