EPCO-23. MOLECULAR CHARACTERIZATION OF CRISPROFF EPIGENETIC EDITOR ACTIVITY REVEALS MUTANT ALLELE-SPECIFIC TERT REPRESSION IN GLIOBLASTOMA
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DOI: 10.1093/neuonc/noaf201.0023
Abstract: Telomerase reactivation via mutations in the telomerase reverse transcriptase promoter (TERTp) is a recurrent feature of glioblastoma, enabling replicative immortality in ~80% of patient cases and presents a critical oncogenic event attractive for therapeutic targeting.… read more here.
Keywords: tertp; mutant allele; glioblastoma; crisproff ... See more keywords