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Massive transfusions for critical bleeding: is everything old new again?

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1 Published in 2018 at "Transfusion Medicine"

DOI: 10.1111/tme.12524

Abstract: Massive transfusion or major haemorrhage protocols have been widely adopted in the treatment of critically bleeding patients. Following evidence that higher ratios of transfused plasma and platelets to red blood cells may offer survival benefits… read more here.

Keywords: everything old; transfusion; massive transfusions; critical bleeding ... See more keywords

Life‐threatening hemorrhage as defined by the critical administration threshold in nontraumatic critical bleeding: A descriptive observational study

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0 Published in 2024 at "Transfusion"

DOI: 10.1111/trf.17996

Abstract: Evaluations of critical bleeding and massive transfusion have focused on traumatic hemorrhage. However, most critical bleeding in hospitalized patients occurs outside trauma. The purpose of this study was to provide an in‐depth description examining the… read more here.

Keywords: critical bleeding; critical administration; hemorrhage; administration threshold ... See more keywords

Critical Bleeding in Adults and Children with Immune Thrombocytopenia: A Multicentre Cohort Study

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0 Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-210851

Abstract: Introduction Immune thrombocytopenia (ITP) is a rare autoimmune disease that causes low blood platelets and an increased risk of bleeding. Critical bleeds in patients with ITP such as intracranial hemorrhage (ICH) are life-threatening events that… read more here.

Keywords: adults children; thrombocytopenia; critical bleeding; itp ... See more keywords

Critical bleeding in adults and children with immune thrombocytopenia: a multicenter cohort study

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0 Published in 2025 at "Blood Advances"

DOI: 10.1182/bloodadvances.2024015494

Abstract: Key Points • Although rare, critical ITP bleeding was fatal (47% of adults; 15% of children), with higher mortality in older cases and delayed treatment.• The combination of corticosteroids, IV immunoglobulin, and platelet transfusion was… read more here.

Keywords: adults children; critical bleeding; immune thrombocytopenia; thrombocytopenia multicenter ... See more keywords

Treatment of critical bleeding events in patients with immune thrombocytopenia: a protocol for a systematic review and meta-analysis

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0 Published in 2024 at "Systematic Reviews"

DOI: 10.1186/s13643-023-02436-6

Abstract: Background Critical bleeding events in adults and children with ITP are medical emergencies; however, evidence-based treatment protocols are lacking. Due to the severe thrombocytopenia, (typically platelet count less than 20 × 10^9/L), a critical bleed portends a… read more here.

Keywords: bleeding; critical bleeding; systematic review; meta analysis ... See more keywords