Circulating B10 regulatory cells are decreased in severe and critical COVID‐19
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.5covcra0721-387rr
Abstract: The contribution of B cells in COVID‐19 pathogenesis, beyond the production of specific antibodies against SARS‐CoV‐2, is still not well understood. Since one of their most relevant functional roles includes their immune‐suppressive mechanisms, we decided… read more here.
Keywords: regulatory cells; critical covid; severe critical; circulating b10 ... See more keywords
Enhanced eosinophil-mediated inflammation associated with antibody and complement-dependent pneumonic insults in critical COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.109798
Abstract: Despite the worldwide effect of the Coronavirus disease 2019 (COVID-19) pandemic, the underlying mechanisms of fatal viral pneumonia remain elusive. Here, we show that critical COVID-19 is associated with enhanced eosinophil-mediated inflammation when compared to… read more here.
Keywords: eosinophil mediated; mediated inflammation; covid; critical covid ... See more keywords
Pulmonary Function and Radiologic Features in Survivors of Critical COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Chest"
DOI: 10.1016/j.chest.2021.02.062
Abstract: Background More than 20% of hospitalized patients with coronavirus disease 2019 (COVID-19) develop acute respiratory distress syndrome (ARDS) requiring intensive care unit (ICU) admission. The long-term respiratory sequelae in ICU survivors remain unclear. Research question… read more here.
Keywords: pulmonary function; function radiologic; covid; icu ... See more keywords
CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Infectious Diseases"
DOI: 10.1016/j.ijid.2020.10.101
Abstract: Objective Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is now a global pandemic. Emerging results indicate a dysregulated immune response. Given the role of CCR5 in immune cell migration and inflammation, we investigated… read more here.
Keywords: covid patients; sars cov2; ccr5; critical covid ... See more keywords
Diagnostic Value of Natural Killer Cells, CD56+ CD16+ Natural Killer Cells, NLRP3, and Lactate Dehydrogenase in Severe/Critical COVID-19: A Prospective Longitudinal Study According to the Severe/Critical COVID-19 Definitions.
Sign Up to like & getrecommendations! Published in 2022 at "Viral immunology"
DOI: 10.1089/vim.2022.0060
Abstract: Innate immunity, as the first line of defense of our immune system, plays a crucial role in defending against SARS-CoV-2 infection and also its immunopathogenesis. We aim to investigate the immune status of natural killer… read more here.
Keywords: critical covid; natural killer; killer cells; covid ... See more keywords
Relative tachycardia at admission as a predictor of mortality in severe and critical COVID-19, a tertiary centre study
Sign Up to like & getrecommendations! Published in 2023 at "Europace"
DOI: 10.1093/europace/euad122.770
Abstract: Abstract Funding Acknowledgements Type of funding sources: None. Background Relative tachycardia is the phenomenon of disproportionate tachycardia in response to fever, originally described in the context of systemic inflammatory response syndrome (SIRS) (1). Systemic COVID-19… read more here.
Keywords: relative tachycardia; tachycardia; mortality; critical covid ... See more keywords
450. Type I Interferon Autoantibodies Are Detected in Those with Critical COVID-19, Including a Young Female Patient
Sign Up to like & getrecommendations! Published in 2021 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofab466.649
Abstract: Abstract Background Approximately 10-20% of patients with critical COVID-19 harbor neutralizing autoantibodies (auto-Abs) that target type I interferons (IFN), a family of cytokines that induce critical innate immune defense mechanisms upon viral infection. Studies to… read more here.
Keywords: support; critical covid; covid; auto ... See more keywords
Progression to Critical Illness and Death in Patients With Breakthrough Hospitalizations
Sign Up to like & getrecommendations! Published in 2022 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofac213
Abstract: Abstract Background Characterization of disease progression and outcomes after coronavirus disease 2019 (COVID-19)–related hospitalization in vaccinated compared with unvaccinated individuals is limited. Methods This was a retrospective case–control study of symptomatic vaccinated (cases) and unvaccinated… read more here.
Keywords: vaccination; illness; covid; progression critical ... See more keywords
Timing of tofacitinib therapy is critical to improving outcomes in severe-critical COVID-19 infection: A retrospective study from a tertiary care hospital
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000030975
Abstract: Describe the use of tofacitinib in severe and critical coronavirus disease-2019 (COVID-19), and explore the association of drug initiation time with survival. A retrospective study of inpatients with severe or critical COVID-19 at a tertiary… read more here.
Keywords: retrospective study; severe critical; tofacitinib; covid ... See more keywords
Microvascular Dysfunction in Patients with Critical COVID-19, A Pilot Study.
Sign Up to like & getrecommendations! Published in 2021 at "Shock"
DOI: 10.1097/shk.0000000000001803
Abstract: BACKGROUND Endothelial and microvascular dysfunction may be a key pathogenic feature of severe COVID-19. The aim of this study was to investigate endothelial-dependent and endothelial-independent skin microvascular reactivity in patients with critical COVID-19. METHODS Twelve… read more here.
Keywords: patients critical; pilot study; microvascular dysfunction; study ... See more keywords
Purple toes following critical COVID‐19 infection
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Dermatology"
DOI: 10.1111/pde.15075
Abstract: left first toe was obtained. Topical fluocinonide was applied to the rash twice daily with gradual improvement of her pain and read more here.
Keywords: covid infection; purple toes; following critical; toes following ... See more keywords