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   Articles with "critical determinant" as a keyword



ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response

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recommendations! Published in 2020 at "iScience"

DOI: 10.1016/j.isci.2020.100860

Abstract: Summary The unfolded protein response (UPR) pathway senses unfolded proteins and regulates proteostasis and cell fate through activity of the transcription factors ATF4, ATF6, and XBP1 within a complex network of three main branches. Here,… read more here.

Keywords: atf6 critical; unfolded protein; protein response; critical determinant ... See more keywords

Is the SPLUNC1-Orai1 axis a critical determinant of lung health?

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recommendations! Published in 2025 at "Biochemical Society Transactions"

DOI: 10.1042/bst20241029

Abstract: Short palate lung and nasal epithelial clone 1 (SPLUNC1; gene name BPIFA1) is a secreted protein that is highly expressed in the nasopharyngeal and pulmonary systems. By data mining, we found that SPLUNC1 is also… read more here.

Keywords: critical determinant; axis critical; lung; splunc1 ... See more keywords

RNAi is a critical determinant of centromere evolution in closely related fungi

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recommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.1713725115

Abstract: Significance The “centromere paradox” refers to rapidly evolving and highly diverse centromere DNA sequences even in closely related eukaryotes. However, factors contributing to this rapid divergence are largely unknown. Here, we identified large regional, LTR… read more here.

Keywords: closely related; evolution; rnai; cytosine dna ... See more keywords

Enforcement of stem-cell dormancy by nucleophosmin mutation is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

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recommendations! Published in 2025 at "Haematologica"

DOI: 10.3324/haematol.2024.286577

Abstract: Mutations in the NPM1 gene (NPMc+) and in the FLT3 gene (FLT3-ITD) represent the most frequent co-occurring mutations in acute myeloid leukemia (AML), yet the cellular and molecular mechanisms of their co-operation remain largely unexplored.… read more here.

Keywords: critical determinant; stem; hsc; self renewal ... See more keywords