Sub-critical impact inhibits the lubricating mechanisms of articular cartilage.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of biomechanics"
DOI: 10.1016/j.jbiomech.2016.12.034
Abstract: Although post-traumatic osteoarthritis accounts for a significant proportion of all osteoarthritis, the understanding of both biological and mechanical phenomena that lead to cartilage degeneration in the years to decades after trauma is still lacking. In… read more here.
Keywords: inhibits lubricating; impact; impact inhibits; critical impact ... See more keywords
Water envelope has a critical impact on the design of protein-protein interaction inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/c9cc07714f
Abstract: We show that a water envelope network plays a critical role in protein-protein interactions (PPI). The potency of a PPI inhibitor is modulated by orders of magnitude on manipulation of the solvent envelope alone. The… read more here.
Keywords: protein; envelope critical; protein protein; water envelope ... See more keywords
Optimizing hybrid LC-MS/MS binding conditions is critical: impact of biotransformation on quantification of trastuzumab.
Sign Up to like & getrecommendations! Published in 2018 at "Bioanalysis"
DOI: 10.4155/bio-2018-0196
Abstract: BACKGROUND Hybrid ligand-binding (LB) LC-MS/MS protein quantitative assays involve a LB step for analyte enrichment that has less stringent requirements than the conventional LB assays. RESULTS Herceptin™(trastuzumab) binding to HER2 extracellular domain was evaluated using… read more here.
Keywords: binding conditions; optimizing hybrid; hybrid binding; conditions critical ... See more keywords