Metallochaperones: A critical regulator of metal homeostasis and beyond.
Sign Up to like & getrecommendations! Published in 2022 at "Gene"
DOI: 10.1016/j.gene.2022.146352
Abstract: Metallochaperones are a class of unique protein families that was originally found to interact with cellular metal ions by metal delivery to specific target proteins such as metal enzymes. Recently, some members of metallochaperones receive… read more here.
Keywords: metal homeostasis; metal; regulator metal; metallochaperones critical ... See more keywords
A critical regulator of Bcl2 revealed by systematic transcript discovery of lncRNAs associated with T-cell differentiation
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DOI: 10.1038/s41598-019-41247-5
Abstract: Normal T-cell differentiation requires a complex regulatory network which supports a series of maturation steps, including lineage commitment, T-cell receptor (TCR) gene rearrangement, and thymic positive and negative selection. However, the underlying molecular mechanisms are… read more here.
Keywords: cell differentiation; bcl2; critical regulator; cell ... See more keywords
Thrombospondin-2 acts as a critical regulator of cartilage regeneration: A review
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DOI: 10.1097/md.0000000000033651
Abstract: The degeneration of articular cartilage tissue is the most common cause of articular cartilage diseases such as osteoarthritis. There are limitations in chondrocyte self-renewal and conventional treatments. During cartilage regeneration and repair, growth factors are… read more here.
Keywords: acts critical; cartilage; thrombospondin acts; cartilage regeneration ... See more keywords
Angiopoietin-like 4 is a critical regulator of fibroblasts during pulmonary fibrosis development.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2022-0304oc
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and irreversible interstitial pneumonia caused by the excessive production and deposition of extracellular matrix components, including type I collagen. Activated fibroblasts, called α-smooth muscle actin (α-SMA)-expressing myofibroblasts,… read more here.
Keywords: pulmonary fibrosis; like critical; angiopoietin like; angptl4 ... See more keywords
NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma
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DOI: 10.7554/elife.46551
Abstract: Squamous cell carcinomas (SCCs) account for the majority of cancer mortalities. Although TP63 is an established lineage-survival oncogene in SCCs, therapeutic strategies have not been developed to target TP63 or it’s downstream effectors. In this… read more here.
Keywords: critical regulator; regulator differentiation; nrg1 critical; cell ... See more keywords