TSPYL1 as a Critical Regulator of TGFβ Signaling through Repression of TGFBR1 and TSPYL2
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202306486
Abstract: Nucleosome assembly proteins (NAPs) have been identified as histone chaperons. Testis‐Specific Protein, Y‐Encoded‐Like (TSPYL) is a newly arisen NAP family in mammals. TSPYL2 can be transcriptionally induced by DNA damage and TGFβ causing proliferation arrest.… read more here.
Keywords: tspyl1 critical; critical regulator; tgf signaling; tspyl2 ... See more keywords
CEP162: A critical regulator of ciliary transition zone assembly and its implications in ciliopathies
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cell Communication and Signaling"
DOI: 10.1002/ccs3.70012
Abstract: CEP162, a 162‐kDa centrosome protein, is a crucial centrosomal adapter, mediating cell differentiation and polarization. CEP162 maintains mitosis by dynamically stabilizing microtubules. CEP162 promotes the transition zone (TZ) assembly in the basal body through interaction… read more here.
Keywords: transition zone; critical regulator; cep162 critical; zone assembly ... See more keywords
Metallochaperones: A critical regulator of metal homeostasis and beyond.
Sign Up to like & getrecommendations! Published in 2022 at "Gene"
DOI: 10.1016/j.gene.2022.146352
Abstract: Metallochaperones are a class of unique protein families that was originally found to interact with cellular metal ions by metal delivery to specific target proteins such as metal enzymes. Recently, some members of metallochaperones receive… read more here.
Keywords: metal homeostasis; metal; regulator metal; metallochaperones critical ... See more keywords
A critical regulator of Bcl2 revealed by systematic transcript discovery of lncRNAs associated with T-cell differentiation
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41247-5
Abstract: Normal T-cell differentiation requires a complex regulatory network which supports a series of maturation steps, including lineage commitment, T-cell receptor (TCR) gene rearrangement, and thymic positive and negative selection. However, the underlying molecular mechanisms are… read more here.
Keywords: cell differentiation; bcl2; critical regulator; cell ... See more keywords
Thrombospondin-2 acts as a critical regulator of cartilage regeneration: A review
Sign Up to like & getrecommendations! Published in 2023 at "Medicine"
DOI: 10.1097/md.0000000000033651
Abstract: The degeneration of articular cartilage tissue is the most common cause of articular cartilage diseases such as osteoarthritis. There are limitations in chondrocyte self-renewal and conventional treatments. During cartilage regeneration and repair, growth factors are… read more here.
Keywords: acts critical; cartilage; thrombospondin acts; cartilage regeneration ... See more keywords
Angiopoietin-like 4 is a critical regulator of fibroblasts during pulmonary fibrosis development.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2022-0304oc
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and irreversible interstitial pneumonia caused by the excessive production and deposition of extracellular matrix components, including type I collagen. Activated fibroblasts, called α-smooth muscle actin (α-SMA)-expressing myofibroblasts,… read more here.
Keywords: pulmonary fibrosis; like critical; angiopoietin like; angptl4 ... See more keywords
MLL1 Complex Is a Critical Regulator of Fetal Hemoglobin Repression
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-199305
Abstract: Increasing fetal-type hemoglobin (HbF) expression in adult erythroid cells represents a promising strategy for treating β-globinopathies including sickle cell disease and β-thalassemia. However, the mechanisms responsible for the repression of HbF expression in adult erythroid… read more here.
Keywords: bcl11a; complex critical; mll1 complex; expression ... See more keywords
miR-34 as a Critical Regulator in Ovarian Cancer.
Sign Up to like & getrecommendations! Published in 2025 at "Current molecular medicine"
DOI: 10.2174/0115665240345216241120093846
Abstract: Ovarian cancer (OC) is a gynecologic disease characterized by the uncontrolled growth and proliferation of abnormal cells in the ovaries, fallopian tubes, or peritoneum. Emerging evidence has shown the pivotal role of non-coding RNAs (ncRNAs),… read more here.
Keywords: cancer; mir critical; ovarian cancer; critical regulator ... See more keywords
NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.46551
Abstract: Squamous cell carcinomas (SCCs) account for the majority of cancer mortalities. Although TP63 is an established lineage-survival oncogene in SCCs, therapeutic strategies have not been developed to target TP63 or it’s downstream effectors. In this… read more here.
Keywords: critical regulator; regulator differentiation; nrg1 critical; cell ... See more keywords