Treatment of Critical-Sized Calvarial Defects in Rats with Preimplanted Transplants.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201900722
Abstract: The local environment and the defect features have made the skull one of the most difficult regions to repair. Finding alternative strategies to repair large cranial defects, thereby avoiding the current limitations of autograft or… read more here.
Keywords: sized calvarial; calvarial defects; critical sized; bone ... See more keywords
Guided Bone Regeneration with a Nitric-Oxide Releasing Polymer Inducing Angiogenesis and Osteogenesis in Critical-Sized Bone Defects.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200162
Abstract: Synthetic scaffolds, as bone grafts, provide a favorable environment for the repair and growth of new bone tissue at defect sites. However, the lack of angio- and osteo-induction limits the usefulness of artificial scaffolds for… read more here.
Keywords: regeneration; bone; regeneration nitric; nitric oxide ... See more keywords
Bone morphogenetic protein 2-induced cellular chemotaxis drives tissue patterning during critical-sized bone defect healing: an in silico study
Sign Up to like & getrecommendations! Published in 2021 at "Biomechanics and Modeling in Mechanobiology"
DOI: 10.1007/s10237-021-01466-0
Abstract: Critical-sized bone defects are critical healing conditions that, if left untreated, often lead to non-unions. To reduce the risk, critical-sized bone defects are often treated with recombinant human BMP-2. Although enhanced bone tissue formation is… read more here.
Keywords: tissue patterning; bmp; bone defect; critical sized ... See more keywords
Periosteum-Mimicking Tissue-Engineered Composite for Treating Periosteum Damage in Critical-Sized Bone Defects.
Sign Up to like & getrecommendations! Published in 2021 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.1c00319
Abstract: The periosteum is an indispensable part of the bone that nourishes the cortical bone and acts as a repertoire of osteoprogenitor cells. Periosteal damage as a result of traumatic injuries, infections, or surgical assistance in… read more here.
Keywords: bone formation; critical sized; periosteum mimicking; bone ... See more keywords
Angio-osteogenic capacity of octacalcium phosphate co-precipitated with copper gluconate in rat calvaria critical-sized defect
Sign Up to like & getrecommendations! Published in 2022 at "Science and Technology of Advanced Materials"
DOI: 10.1080/14686996.2022.2035193
Abstract: ABSTRACT The objective of this study is to investigate the effects of octacalcium phosphate (OCP)-induced bone regeneration on angiogenesis regulated by the inclusion of copper ions in OCP in vitro and in vivo. Calcium (Ca)-deficient… read more here.
Keywords: octacalcium phosphate; ocp; sized defect; critical sized ... See more keywords
Treatment of the Critical-Sized Bone Defect Involving the Ankle Joint: Staged Tibiotalocalcaneal Arthrodesis With Induced Membrane Technique and Intramedullary Nail.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of orthopaedic trauma"
DOI: 10.1097/bot.0000000000002363
Abstract: OBJECTIVES To report the outcomes of staged tibiotalocalcaneal (TTC) arthrodesis for the critical-sized bone defect involving the ankle joint. DESIGN Retrospective review of case series. SETTING Two academic level I trauma centers.Patients/Participants: 20 patients with… read more here.
Keywords: arthrodesis; bone defect; critical sized; ankle joint ... See more keywords
Macrophage Transplantation Fails to Improve Repair of Critical-Sized Calvarial Defects.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Craniofacial Surgery"
DOI: 10.1097/scs.0000000000005797
Abstract: INTRODUCTION Over 500,000 bone grafting procedures are performed every year in the United States for neoplastic and traumatic lesions of the craniofacial skeleton, costing $585 million in medical care. Current bone grafting procedures are limited,… read more here.
Keywords: histology; critical sized; transplantation; bone ... See more keywords
Regeneration of Critical-Sized Grade II Furcation Using a Novel Injectable Melatonin-Loaded Scaffold.
Sign Up to like & getrecommendations! Published in 2022 at "Oral diseases"
DOI: 10.1111/odi.14314
Abstract: BACKGROUND Periodontal regenerative therapy using bone-substituting materials has gained favorable clinical significance in enhancing osseous regeneration. These materials should be biocompatible, osteogenic, malleable, and biodegradable. This study assessed the periodontal regenerative capacity of a novel… read more here.
Keywords: regeneration; melatonin loaded; bone; critical sized ... See more keywords
Cell spheroids are as effective as single cells suspensions in the treatment of critical-sized bone defects
Sign Up to like & getrecommendations! Published in 2021 at "BMC Musculoskeletal Disorders"
DOI: 10.1186/s12891-021-04264-y
Abstract: Background Due to their multilineage potential and high proliferation rate, mesenchymal stem cells (MSC) indicate a sufficient alternative in regenerative medicine. In comparison to the commonly used 2-dimensional culturing method, culturing cells as spheroids stimulates… read more here.
Keywords: critical sized; msc suspensions; msc spheroids; bone ... See more keywords
Convergence of scaffold-guided bone regeneration and RIA bone grafting for the treatment of a critical-sized bone defect of the femoral shaft
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Medical Research"
DOI: 10.1186/s40001-020-00471-w
Abstract: Background Critical-sized bone defects, mainly from trauma, infection or tumor resection are a challenging condition, often resulting in prolonged, complicated course of treatment. Autografts are considered as the gold standard to replace lost bone. However,… read more here.
Keywords: femoral shaft; mpcl tcp; treatment; critical sized ... See more keywords
Low power laser irradiation and human adipose-derived stem cell treatments promote bone regeneration in critical-sized calvarial defects in rats
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0195337
Abstract: Both stem cell therapy and physical treatments have been shown to be beneficial in accelerating bone healing. However, the efficacy of combined treatment with stem cells and physical stimuli for large bone defects remains uncertain.… read more here.
Keywords: sized calvarial; critical sized; group; bone ... See more keywords