Treatment of Critical-Sized Calvarial Defects in Rats with Preimplanted Transplants.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201900722
Abstract: The local environment and the defect features have made the skull one of the most difficult regions to repair. Finding alternative strategies to repair large cranial defects, thereby avoiding the current limitations of autograft or… read more here.
Keywords: sized calvarial; calvarial defects; critical sized; bone ... See more keywords
Mobilizing Endogenous Progenitor Cells Using pSDF1α‐Activated Scaffolds Accelerates Angiogenesis and Bone Repair in Critical‐Sized Bone Defects
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202401031
Abstract: Mobilizing endogenous progenitor cells to repair damaged tissue in situ has the potential to revolutionize the field of regenerative medicine, while the early establishment of a vascular network will ensure survival of newly generated tissue.… read more here.
Keywords: endogenous progenitor; sized bone; bone; mobilizing endogenous ... See more keywords
Guided Bone Regeneration with a Nitric-Oxide Releasing Polymer Inducing Angiogenesis and Osteogenesis in Critical-Sized Bone Defects.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200162
Abstract: Synthetic scaffolds, as bone grafts, provide a favorable environment for the repair and growth of new bone tissue at defect sites. However, the lack of angio- and osteo-induction limits the usefulness of artificial scaffolds for… read more here.
Keywords: regeneration; bone; regeneration nitric; nitric oxide ... See more keywords
Bone morphogenetic protein 2-induced cellular chemotaxis drives tissue patterning during critical-sized bone defect healing: an in silico study
Sign Up to like & getrecommendations! Published in 2021 at "Biomechanics and Modeling in Mechanobiology"
DOI: 10.1007/s10237-021-01466-0
Abstract: Critical-sized bone defects are critical healing conditions that, if left untreated, often lead to non-unions. To reduce the risk, critical-sized bone defects are often treated with recombinant human BMP-2. Although enhanced bone tissue formation is… read more here.
Keywords: tissue patterning; bmp; bone defect; critical sized ... See more keywords
Periosteum-Mimicking Tissue-Engineered Composite for Treating Periosteum Damage in Critical-Sized Bone Defects.
Sign Up to like & getrecommendations! Published in 2021 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.1c00319
Abstract: The periosteum is an indispensable part of the bone that nourishes the cortical bone and acts as a repertoire of osteoprogenitor cells. Periosteal damage as a result of traumatic injuries, infections, or surgical assistance in… read more here.
Keywords: bone formation; critical sized; periosteum mimicking; bone ... See more keywords
Self-reinforced piezoelectric chip for scaffold-free repair of critical-sized bone defects
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-61243-w
Abstract: The use of piezoelectric materials to treat critical-sized bone defects typically requires additional stimulation to generate their piezoelectric properties and the implantation of scaffolds to promote bone repair. Here we present a self-reinforced piezoelectric chip… read more here.
Keywords: bone defects; repair; sized bone; chip ... See more keywords
Angio-osteogenic capacity of octacalcium phosphate co-precipitated with copper gluconate in rat calvaria critical-sized defect
Sign Up to like & getrecommendations! Published in 2022 at "Science and Technology of Advanced Materials"
DOI: 10.1080/14686996.2022.2035193
Abstract: ABSTRACT The objective of this study is to investigate the effects of octacalcium phosphate (OCP)-induced bone regeneration on angiogenesis regulated by the inclusion of copper ions in OCP in vitro and in vivo. Calcium (Ca)-deficient… read more here.
Keywords: octacalcium phosphate; ocp; sized defect; critical sized ... See more keywords
Treatment of the Critical-Sized Bone Defect Involving the Ankle Joint: Staged Tibiotalocalcaneal Arthrodesis With Induced Membrane Technique and Intramedullary Nail.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of orthopaedic trauma"
DOI: 10.1097/bot.0000000000002363
Abstract: OBJECTIVES To report the outcomes of staged tibiotalocalcaneal (TTC) arthrodesis for the critical-sized bone defect involving the ankle joint. DESIGN Retrospective review of case series. SETTING Two academic level I trauma centers.Patients/Participants: 20 patients with… read more here.
Keywords: arthrodesis; bone defect; critical sized; ankle joint ... See more keywords
Macrophage Transplantation Fails to Improve Repair of Critical-Sized Calvarial Defects.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Craniofacial Surgery"
DOI: 10.1097/scs.0000000000005797
Abstract: INTRODUCTION Over 500,000 bone grafting procedures are performed every year in the United States for neoplastic and traumatic lesions of the craniofacial skeleton, costing $585 million in medical care. Current bone grafting procedures are limited,… read more here.
Keywords: histology; critical sized; transplantation; bone ... See more keywords
Regeneration of Critical-Sized Grade II Furcation Using a Novel Injectable Melatonin-Loaded Scaffold.
Sign Up to like & getrecommendations! Published in 2022 at "Oral diseases"
DOI: 10.1111/odi.14314
Abstract: BACKGROUND Periodontal regenerative therapy using bone-substituting materials has gained favorable clinical significance in enhancing osseous regeneration. These materials should be biocompatible, osteogenic, malleable, and biodegradable. This study assessed the periodontal regenerative capacity of a novel… read more here.
Keywords: regeneration; melatonin loaded; bone; critical sized ... See more keywords
Cell spheroids are as effective as single cells suspensions in the treatment of critical-sized bone defects
Sign Up to like & getrecommendations! Published in 2021 at "BMC Musculoskeletal Disorders"
DOI: 10.1186/s12891-021-04264-y
Abstract: Background Due to their multilineage potential and high proliferation rate, mesenchymal stem cells (MSC) indicate a sufficient alternative in regenerative medicine. In comparison to the commonly used 2-dimensional culturing method, culturing cells as spheroids stimulates… read more here.
Keywords: critical sized; msc suspensions; msc spheroids; bone ... See more keywords