Crizotinib Nanomicelles Synergize with Chemotherapy through Inducing Proteasomal Degradation of Mutp53 Proteins.
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DOI: 10.1021/acsami.2c18020
Abstract: TP53 missense mutations that express highly stabilized mutant p53 protein (mutp53) driving tumorigenesis have been witnessed in a considerable percentage of human cancers. The attempt to induce degradation of mutp53 has thus been an attractive… read more here.
Keywords: crizotinib nanomicelles; degradation mutp53; mutp53; proteasomal degradation ... See more keywords