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   Articles with "crkl" as a keyword



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Requirement for Crk and CrkL during postnatal lens development.

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recommendations! Published in 2020 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2020.06.108

Abstract: The Crk and CrkL adaptor proteins have SH2 and SH3 domains and play essential overlapping, as well as distinct, roles in many biological processes, ranging from cell structure and motility to proliferation. Conditional ablation of… read more here.

Keywords: lens development; crkl; postnatal lens; crk crkl ... See more keywords

HDAC inhibitor suppresses proliferation and invasion of breast cancer cells through regulation of miR‐200c targeting CRKL

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recommendations! Published in 2018 at "Biochemical Pharmacology"

DOI: 10.1016/j.bcp.2017.11.008

Abstract: ABSTRACT Although histone deacetylase (HDAC) inhibitors have been shown to effectively induce the inhibition of proliferation and migration in breast cancer, the anticancer mechanism remains poorly understood. Our studies show that miR‐200c was significantly downregulated… read more here.

Keywords: crkl; hdac; mir 200c; breast cancer ... See more keywords

miR-429 suppresses tumor migration and invasion by targeting CRKL in hepatocellular carcinoma via inhibiting Raf/MEK/ERK pathway and epithelial-mesenchymal transition

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-20258-8

Abstract: Tumor metastasis is one of the main causes of hepatocellular carcinoma (HCC) high mortality. CRKL (v-crk sarcoma virus CT10 oncogene homologue (avian)-like) play important roles in tumor metastasis, however, the exact role and underlying mechanism… read more here.

Keywords: mir 429; crkl; migration invasion; raf mek ... See more keywords

CRKL but not CRKII contributes to hemin‐induced erythroid differentiation of CML

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recommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.18308

Abstract: Destruction of erythropoiesis process leads to various diseases, including thrombocytopenia, anaemia, and leukaemia. miR‐429‐CT10 regulation of kinase‐like (CRKL) axis involved in development, progression and metastasis of cancers. However, the exact role of miR‐429‐CRKL axis in… read more here.

Keywords: k562 cells; crkl; mir 429; erythroid differentiation ... See more keywords

CRISPR Dropout Screens Identify DHODH,PIK3C3, and Crkl as Potential Therapeutic Targets in Acute Myeloid Leukemia

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recommendations! Published in 2019 at "Blood"

DOI: 10.1182/blood-2019-128180

Abstract: Relapsed disease is still a major challenge in AML despite recently approved targeted therapies. New therapeutic targets are needed. To identify vulnerabilities in AML, screening data from a lentiviral-based genome-wide pooled CRISPR-Cas9 library (DepMap) was… read more here.

Keywords: crkl; crispr cas9; therapeutic targets; aml ... See more keywords