LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "crkl" as a keyword



Photo by bermixstudio from unsplash

Requirement for Crk and CrkL during postnatal lens development.

Sign Up to like & get
recommendations! Published in 2020 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2020.06.108

Abstract: The Crk and CrkL adaptor proteins have SH2 and SH3 domains and play essential overlapping, as well as distinct, roles in many biological processes, ranging from cell structure and motility to proliferation. Conditional ablation of… read more here.

Keywords: lens development; crkl; postnatal lens; crk crkl ... See more keywords
Photo by art_almighty from unsplash

HDAC inhibitor suppresses proliferation and invasion of breast cancer cells through regulation of miR‐200c targeting CRKL

Sign Up to like & get
recommendations! Published in 2018 at "Biochemical Pharmacology"

DOI: 10.1016/j.bcp.2017.11.008

Abstract: ABSTRACT Although histone deacetylase (HDAC) inhibitors have been shown to effectively induce the inhibition of proliferation and migration in breast cancer, the anticancer mechanism remains poorly understood. Our studies show that miR‐200c was significantly downregulated… read more here.

Keywords: crkl; hdac; mir 200c; breast cancer ... See more keywords
Photo by art_almighty from unsplash

miR-429 suppresses tumor migration and invasion by targeting CRKL in hepatocellular carcinoma via inhibiting Raf/MEK/ERK pathway and epithelial-mesenchymal transition

Sign Up to like & get
recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-20258-8

Abstract: Tumor metastasis is one of the main causes of hepatocellular carcinoma (HCC) high mortality. CRKL (v-crk sarcoma virus CT10 oncogene homologue (avian)-like) play important roles in tumor metastasis, however, the exact role and underlying mechanism… read more here.

Keywords: mir 429; crkl; migration invasion; raf mek ... See more keywords
Photo by enginakyurt from unsplash

CRISPR Dropout Screens Identify DHODH,PIK3C3, and Crkl as Potential Therapeutic Targets in Acute Myeloid Leukemia

Sign Up to like & get
recommendations! Published in 2019 at "Blood"

DOI: 10.1182/blood-2019-128180

Abstract: Relapsed disease is still a major challenge in AML despite recently approved targeted therapies. New therapeutic targets are needed. To identify vulnerabilities in AML, screening data from a lentiviral-based genome-wide pooled CRISPR-Cas9 library (DepMap) was… read more here.

Keywords: crkl; crispr cas9; therapeutic targets; aml ... See more keywords