Virulence evolution, molecular mechanisms and prevalence of ST11 Carbapenem-resistant Klebsiella pneumoniae in China: A review over ten last years.
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DOI: 10.1016/j.jgar.2020.09.004
Abstract: ST11 carbapenem-resistant K. pneumoniae (CRKP) has been the dominant clone in China. In this review, we trace the prevalence of ST11 CRKP in China Antimicrobial Surveillance Network (CHINET), the key drug resistance mechanisms, and virulence… read more here.
Keywords: st11; crkp; virulence; prevalence st11 ... See more keywords
Epidemiology and genotypic characteristics of carbapenem resistant Enterobacterales in Henan, China: A multicentre study.
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DOI: 10.1016/j.jgar.2022.01.029
Abstract: OBJECTIVES To identify the carbapenemase and colistin resistance genes and epidemiological status of carbapenem resistant Enterobacterales (CRE) among 7 secondary and 11 tertiary hospitals in Henan province, China. METHODS CRE isolates and clinical data of… read more here.
Keywords: epidemiology; carbapenem resistant; secondary tertiary; crkp ... See more keywords
Prevalence of ST1049-KL5 carbapenem-resistant Klebsiella pneumoniae with a blaKPC-2 and blaNDM-1 co-carrying hypertransmissible IncM1 plasmid
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DOI: 10.1038/s42003-024-06398-w
Abstract: Infection caused by KPC and NDM carbapenemases co-producing Klebsiella pneumoniae (KPC_NDM_CRKP) poses serious public health concerns. Here, we elucidate the prevalence of a hypertransmissible lncM1 plasmid, pKPC_NDM, co-carrying blaKPC-2 and blaNDM-1 genes in sequence type… read more here.
Keywords: st1049 kl5; pneumoniae; blakpc blandm; plasmid ... See more keywords
Iron metabolism contributes to virulence by enhancing serum resistance in the emerging high-risk clone ST15 CRKP
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DOI: 10.1080/21505594.2025.2569700
Abstract: ABSTRACT ST15 has become one of the most common sequence types of carbapenem-resistant Klebsiella pneumoniae (CRKP) in China; however, the characteristics of ST15 CRKP remains elusive. This study included a total of 72 unique CRKP… read more here.
Keywords: iron; st15; serum resistance; st15 crkp ... See more keywords
Prevalence of Carbapenem-Resistant Klebsiella pneumoniae Infection in Southern China: Clinical Characteristics, Antimicrobial Resistance, Virulence, and Geographic Distribution.
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DOI: 10.1089/mdr.2018.0401
Abstract: Carbapenem-resistant Klebsiella pneumoniae (CRKP) strains pose a significant threat to public health. In this study, a survey was conducted in the Jiangxi Province of China, covering a total of 140 CRKP strains collected from 11… read more here.
Keywords: crkp; pneumoniae; resistance; carbapenem resistant ... See more keywords
Molecular Epidemiology, Microbial Virulence, and Resistance of Carbapenem-Resistant Enterobacterales Isolates in a Teaching Hospital in Guangzhou, China.
Sign Up to like & getrecommendations! Published in 2022 at "Microbial drug resistance"
DOI: 10.1089/mdr.2021.0156
Abstract: Infection caused by carbapenem-resistant Enterobacterales (CRE) is a global public health problem. We performed whole-genome sequencing to investigate the molecular epidemiological characteristics of local CRE infections and understand the prevalence of hypervirulent carbapenem-resistant Klebsiella pneumoniae… read more here.
Keywords: carbapenem resistant; virulence; resistance; crkp ... See more keywords
Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae in a Network of Long-Term Acute Care Hospitals
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DOI: 10.1093/cid/ciw856
Abstract: Background The rapid emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) represents a major public health threat, including in the long-term acute care hospital (LTACH) setting. Our objective in this study was to describe the epidemiologic characteristics… read more here.
Keywords: epidemiology; pneumoniae; acute care; crkp ... See more keywords
In-Human Multiyear Evolution of Carbapenem-Resistant Klebsiella pneumoniae Causing Chronic Colonization and Intermittent Urinary Tract Infections: A Case Study
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DOI: 10.1128/msphere.00190-22
Abstract: Carbapenem-resistant Klebsiella pneumoniae (CRKP) can cause a variety of infections such as recurrent urinary tract infections (rUTI) with the ability to change with the host environment over time. However, it is unclear how CRKP adapts… read more here.
Keywords: urinary tract; time; colonization; tract infections ... See more keywords
Adaptive attenuation of virulence in hypervirulent carbapenem-resistant Klebsiella pneumoniae
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DOI: 10.1128/msystems.01363-23
Abstract: ABSTRACT The emergence of nosocomial infections caused by hypervirulent and carbapenem-resistant K. pneumoniae (hv-CRKP) has become a significant public health challenge. The genetic traits of virulence and resistance plasmids in hv-CRKP have been extensively studied;… read more here.
Keywords: carbapenem resistant; pneumoniae; promoter; virulence ... See more keywords
Emergence of High-Level Cefiderocol Resistance in Carbapenem-Resistant Klebsiella pneumoniae from Bloodstream Infections in Patients with Hematologic Malignancies in China
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DOI: 10.1128/spectrum.00084-22
Abstract: Cefiderocol-resistant CRKP strains are emerging in bloodstream infections in Chinese patients with hematologic malignancies, although cefiderocol has not been approved for clinical use in China. Our study proved that the resistance of CRKP against cefiderocol… read more here.
Keywords: cefiderocol resistance; cira; cefiderocol; resistance ... See more keywords
Risk Factors for the Development of Colistin Resistance during Colistin Treatment of Carbapenem-Resistant Klebsiella pneumoniae Infections
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DOI: 10.1128/spectrum.00381-22
Abstract: Treatment of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections is challenging due to the limited options of antibiotics. Colistin is one of the last-resort antibiotics if novel antimicrobial agents are not available. ABSTRACT Colistin is one of… read more here.
Keywords: colistin; crkp; colistin treatment; treatment ... See more keywords