Ubiquitination of NKCC2 by the cullin-RING E3 ubiquitin ligase family in the thick ascending limb of the loop of Henle
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DOI: 10.1152/ajprenal.00079.2022
Abstract: The Na/K/2Cl cotransporter (NKCC2) in the thick ascending limb of the loop of Henle (TAL) mediates NaCl reabsorption. Cyclic guanosine monophosphate (cGMP), the second messenger of nitric oxide and atrial natriuretic peptide, inhibits NKCC2 activity… read more here.
Keywords: nkcc2 ubiquitination; ubiquitin ligase; physiology; crl complex ... See more keywords