The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels
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DOI: 10.1002/advs.202405812
Abstract: NUMB is a tumor suppressor gene that functions by inhibiting the action of the NOTCH proto-oncogene and enhancing the levels and activity of the tumor suppressor protein p53. In breast cancer (BC), NUMB loss-of-function (LOF),… read more here.
Keywords: complex controls; mammary stem; crl7fbxw8 complex; tumor suppressor ... See more keywords