CRLF2 overexpression defines an immature‐like subgroup which is rescued through restoration of the PRC2 function in T‐cell precursor acute lymphoblastic leukemia
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DOI: 10.1002/gcc.23036
Abstract: CRLF2 overexpression has been described as a biomarker of poor prognosis in T‐cell acute lymphoblastic leukemia (T‐ALL). In the present study, we aimed to unravel the genomic profile underlying CRLF2 overexpression (CRLF2‐high) by analyzing RNA‐seq,… read more here.
Keywords: cell; crlf2; crlf2 high; crlf2 overexpression ... See more keywords
Clinical, biological, and outcome features of P2RY8‐CRLF2 and CRLF2 over‐expression in pediatric B‐cell precursor acute lymphoblastic leukemia according to the CCLG‐ALL 2008 and 2018 protocol
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DOI: 10.1111/ejh.13948
Abstract: CRLF2 alterations are associated with B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL). This study aimed to explore the clinical, biological, and outcome features of pediatric BCP‐ALL with CRLF2 abnormalities. read more here.
Keywords: crlf2; clinical biological; cell precursor; precursor acute ... See more keywords
High-Dose TSLP Induces Co-Receptor Internalization and Signal Shutdown in Ph-like B-ALL with Overexpression of CRLF2
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DOI: 10.1182/blood-2018-99-114336
Abstract: Background. Approximately half of all Ph-like B cell acute lymphoblastic leukemia is characterized by overexpression of CRLF2 (CRLF2 B-ALL). CRLF2 B-ALL is associated with high rates of relapse and is more prevalent in Hispanic children… read more here.
Keywords: high dose; crlf2; dose tslp; tslp ... See more keywords
Outcomes of Patients with Down Syndrome and CRLF2-Overexpressing Acute Lymphoblastic Leukemia (ALL): A Report from the Children's Oncology Group (COG)
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DOI: 10.1182/blood-2020-143165
Abstract: Background: Patients with Down syndrome (DS) have an approximately 10-fold increased risk of developing ALL, and the spectrum of genetic alterations differs from that of non-DS ALL. Rearrangement and/or overexpression of cytokine receptor-like factor 2… read more here.
Keywords: jak; risk; crlf2 cases; crlf2 ... See more keywords
Characterization of Philadelphia-like Pre-B Acute Lymphoblastic Leukemia: Experiences in Mexican Pediatric Patients
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DOI: 10.3390/ijms23179587
Abstract: Ph-like subtypes with CRLF2 abnormalities are frequent among Hispano–Latino children with pre-B ALL. Therefore, there is solid ground to suggest that this subtype is frequent in Mexican patients. The genomic complexity of Ph-like subtype constitutes… read more here.
Keywords: philadelphia like; pre acute; crlf2; characterization philadelphia ... See more keywords
Potential efficacy and prognosis of silencing the CRLF2-mediated AKT/mTOR pathway in pediatric acute B-cell lymphoblastic leukemia
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DOI: 10.3892/or.2018.6917
Abstract: Acute B-cell lymphoblastic leukemia (B-ALL) is a common type of blood cancer, which is associated with aberrant gene expression. Cytokine receptor-like factor 2 (CRLF2) serves a crucial role in the growth and allergic and inflammatory… read more here.
Keywords: mtor pathway; crlf2; mtor; cell ... See more keywords