Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2020006846
Abstract: CRLF2-rearranged (CRLF2r) acute lymphoblastic leukemia (ALL) comprises over half of Philadelphia chromosome-like (Ph-like) ALL, is associated with poor outcome in children and adults. Overexpression of CRLF2 results in activation of JAK-STAT and parallel signaling pathways… read more here.
Keywords: degradation; jak; crlf2 rearranged; leukemia ... See more keywords
Co-occurrence of CRLF2-rearranged and Ph+ acute lymphoblastic leukemia: a report of four patients
Sign Up to like & getrecommendations! Published in 2017 at "Haematologica"
DOI: 10.3324/haematol.2016.161000
Abstract: Ph-like acute lymphoblastic leukemia (Ph-like ALL) represents a high-risk subgroup of B-cell ALL.[1][1]–[7][2] By gene-expression, these patients have a profile similar to that of Ph+ ALL; however, they lack the BCR-ABL1 fusion. Patients with Ph-like… read more here.
Keywords: lymphoblastic leukemia; rearranged acute; crlf2 rearranged; acute lymphoblastic ... See more keywords