Chromosome region maintenance-1 (CRM1) regulates apoptosis of intestinal epithelial cells via p27kip1 in Crohn's disease.
Sign Up to like & getrecommendations! Published in 2017 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2017.01.012
Abstract: OBJECTIVE To investigate the role of chromosome region maintenance-1 (CRM1) in Crohn's disease (CD) and its potential pathological mechanisms. METHODS The expression and distribution of CRM1 in mucosal biopsies from patients with active CD and… read more here.
Keywords: caspase cleaved; active caspase; p27kip1; expression ... See more keywords
Searching for Novel Noncovalent Nuclear Export Inhibitors through a Drug Repurposing Approach.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01772
Abstract: Chromosomal region maintenance protein 1 (CRM1) is a validated anticancer drug target, and its covalent inhibitor KPT-330 has been approved for marketing. However, the development of CRM1 inhibitors, especially the noncovalent ones, is still very… read more here.
Keywords: novel noncovalent; searching novel; drug repurposing; nuclear export ... See more keywords
Durable response with single-agent acalabrutinib in patients with relapsed or refractory mantle cell lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0575-9
Abstract: Winkelmann N, Aranaz P, et al. Mutations in SETBP1 are recurrent in myelodysplastic syndromes and often coexist with cytogenetic markers associated with disease progression. Br J Haematol. 2013;163:235–9. 9. Nguyen N, Vishwakarma BA, Oakley K,… read more here.
Keywords: export; durable response; nuclear export; crm1 ... See more keywords
Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e20-04-0233
Abstract: The E571K mutation of CRM1 is highly prevalent in some cancers, but its mechanism of tumorigenesis is unclear. Glu571 of CRM1 is located in its nuclear export signal (NES)-binding groove, suggesting that binding of select… read more here.
Keywords: nuclear export; crm1 e571k; crm1; e571k ... See more keywords
Inhibition of Autism-Related Crm1 Disrupts Mitosis and Induces Apoptosis of the Cortical Neural Progenitors.
Sign Up to like & getrecommendations! Published in 2020 at "Cerebral cortex"
DOI: 10.1093/cercor/bhaa011
Abstract: De novo microdeletion of chromosome 2p15-16.1 presents clinically recognizable phenotypes that include mental retardation, autism, and microcephaly. Chromosomal maintenance 1 (CRM1) is a gene commonly missing in patients with 2p15-16.1 microdeletion and one of two… read more here.
Keywords: cortical neural; mitosis; autism; apoptosis cortical ... See more keywords
CRM1 inhibitor anti-tumor activity is enhanced with salicylates by S-phase arrest and impaired DNA-damage repair.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2020009013
Abstract: Chromosome region maintenance protein1 (CRM1) mediates protein export from the nucleus and is a new target for anti-cancer therapeutics. Broader application of KPT-330 (selinexor), a first in class CRM1 inhibitor recently approved for relapsed multiple… read more here.
Keywords: dna damage; damage repair; anti tumor; crm1 ... See more keywords
Subcellular Translocation of Yorkie through the PRP4K-CRM1 Axis Regulates Antimicrobial Peptides Transcription and Defense against Bacterial Infection in Crab.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of immunology"
DOI: 10.4049/jimmunol.2200803
Abstract: The Hippo signaling pathway plays important roles in innate immunity. In the current study, we found that bacterial infection did not influence mRNA and protein levels of yorkie (Yki), which is an important terminal molecule… read more here.
Keywords: prp4k; infection; antimicrobial peptides; yki ... See more keywords