Site‐Specific Multi‐Functionalization of the Carrier Protein CRM197 by Disulfide Rebridging for Conjugate Vaccine Development
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200408
Abstract: Conjugation of an antigen to a carrier protein is widely used for vaccine development. To develop the next generation of conjugate vaccines, we describe here a method for the controlled multi‐functionalization of the widely employed… read more here.
Keywords: carrier; functionalization; vaccine development; carrier protein ... See more keywords
Assembly of Immunogenic Protein Particles toward Advanced Synthetic Vaccines.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202205819
Abstract: Immunogenic carrier proteins such as the non-toxic diphtheria toxin variant, cross-reacting material 197 (CRM197), are widely used in subunit vaccine formulations to boost immunogenicity of chemically conjugated antigens. Conjugate vaccines are inherently expensive due to… read more here.
Keywords: protein particles; antigens epitopes; crm197 antigen; immunogenic protein ... See more keywords
CRM197-conjugated peptides vaccine of HCMV pp65 and gH induce maturation of DC and effective viral-specific T cell responses
Sign Up to like & getrecommendations! Published in 2023 at "Virulence"
DOI: 10.1080/21505594.2023.2169488
Abstract: ABSTRACT Human cytomegalovirus (HCMV) infection is prevalent worldwide, and there is currently no licenced HCMV vaccine to control it. Therefore, developing an effective HCMV vaccine is a significant priority. Because of their excellent immunogenicity, the… read more here.
Keywords: pp65; peptide crm197; crm197 vaccines; hcmv vaccine ... See more keywords
Efficient recovery of recombinant CRM197 expressed as inclusion bodies in E.coli
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0201060
Abstract: CRM197, which retains the same inflammatory and immune-stimulant properties as diphtheria toxin but with reduced toxicity, has been used as a safe carrier in conjugated vaccines. Expression of recombinant CRM197 in E. coli is limited… read more here.
Keywords: inclusion bodies; recovery; recombinant crm197; crm197 ... See more keywords
Design, synthesis and primary immunologic evaluation of M2e-CRM197 conjugate as a universal influenza vaccine candidate.
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DOI: 10.2174/1389201021666201104145006
Abstract: BACKGROUND Influenza is a contagious respiratory illness caused by acute infection of influenza viruses, among which influenza A virus causes epidemic seasonal infection nearly every year. Along with unpredictability of evolving influenza A virus and… read more here.
Keywords: m2e crm197; m2e; crm197 conjugate; crm197 ... See more keywords
[Role and mechanism of the regulation of nuclear factor-κB by heparin binding-epidermal growth factor-like growth factor in the induction of paclitaxel resistance of ovarian cancer].
Sign Up to like & getrecommendations! Published in 2019 at "Zhonghua fu chan ke za zhi"
DOI: 10.3760/cma.j.issn.0529-567x.2019.04.008
Abstract: Objective: To investigate the role and mechanism of the regulation of nuclear factor-κB (NF-κB) by heparin binding-epidermal growth factor-like growth factor (HB-EGF) in paclitaxel resistance of ovarian cancer in vitro and in vivo. Methods: (1)… read more here.
Keywords: group; crm197; expression; a2780 taxol ... See more keywords