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   Articles with "crmp2" as a keyword



Isoaspartate formation and irreversible aggregation of collapsin response mediator protein 2: implications for the etiology of epilepsy and age-related cognitive decline

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recommendations! Published in 2024 at "Amino Acids"

DOI: 10.1007/s00726-024-03435-0

Abstract: Collapsin response mediator protein 2 (CRMP2) functions in the genesis and activity of neuronal connections in mammalian brain. We previously reported that a protein coincident with CRMP2 on 2D-gels undergoes marked accumulation of abnormal L-isoaspartyl… read more here.

Keywords: crmp2; etiology; collapsin response; response mediator ... See more keywords

Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking

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recommendations! Published in 2019 at "Molecular Neurobiology"

DOI: 10.1007/s12035-019-01711-9

Abstract: Cocaine addiction remains a major health concern with limited effective treatment options. A better understanding of mechanisms underlying relapse may help inform the development of new pharmacotherapies. Emerging evidence suggests that collapsin response mediator protein… read more here.

Keywords: crmp2; cocaine seeking; reinstatement cocaine; cocaine ... See more keywords

CRMP2 modulates mossy fiber sprouting in dentate gyrus of pilocarpine induced rat model of epilepsy.

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recommendations! Published in 2022 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2022.03.071

Abstract: As a hallmark of epilepsy, mossy fiber sprouting was regarded as an ideal mode to study neural rewiring upon injury. The process of mossy fiber sprouting constitutes key steps for neural circuit formation, including axon… read more here.

Keywords: model epilepsy; fiber sprouting; mossy fiber; crmp2 ... See more keywords

Phosphorylation and SUMOylation of CRMP2 regulate the formation and maturation of dendritic spines

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recommendations! Published in 2018 at "Brain Research Bulletin"

DOI: 10.1016/j.brainresbull.2018.02.004

Abstract: The posttranslational modifications of CRMP2 play an important role in axon outgrowth, cell polarization and dendritic morphogenesis. However, whether CRMP2 and its posttranslational modifications are involved in dendritic spine development specifically is not completely clear.… read more here.

Keywords: crmp2; formation; formation maturation; maturation dendritic ... See more keywords

CRMP2 improves memory deficits by enhancing the maturation of neuronal dendritic spines after traumatic brain injury

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recommendations! Published in 2020 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2020.113253

Abstract: Our recent study investigated the role of collapsin response mediator protein-2 (CRMP2) on dendritic spine morphology and memory function after traumatic brain injury (TBI). First, we examined the density and morphology of dendritic spines in… read more here.

Keywords: dendritic spine; crmp2; density; type ... See more keywords

Peroxiredoxin interaction with the cytoskeletal‐regulatory protein CRMP2: Investigation of a putative redox relay

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recommendations! Published in 2018 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2018.10.407

Abstract: &NA; Hydrogen peroxide (H2O2) acts as a signaling molecule in cells by oxidising cysteine residues in regulatory proteins such as phosphatases, kinases and transcription factors. It is unclear exactly how many of these proteins are… read more here.

Keywords: protein; oxidation; relay; crmp2 ... See more keywords

CRMP2 mediates GSK3β actions in the striatum on regulating neuronal structure and mania-like behavior.

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recommendations! Published in 2019 at "Journal of affective disorders"

DOI: 10.1016/j.jad.2018.10.371

Abstract: BACKGROUND Genetic and physiological studies have implicated the striatum in bipolar disorder (BD). Although Glycogen synthase kinase 3 beta (GSK3β) has been suggested to play a role in the pathophysiology of BD since it is… read more here.

Keywords: mania like; crmp2; like behavior; structure ... See more keywords

CRMP2–Neurofibromin Interface Drives NF1-related Pain

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recommendations! Published in 2018 at "Neuroscience"

DOI: 10.1016/j.neuroscience.2018.04.002

Abstract: An understudied symptom of the genetic disorder Neurofibromatosis type 1 (NF1) is chronic idiopathic pain. We used targeted editing of Nf1 in rats to provide direct evidence of a causal relationship between neurofibromin, the protein… read more here.

Keywords: crmp2 neurofibromin; nf1 related; crmp2; neurofibromin interface ... See more keywords

Protein tyrosine phosphatase 4A3 (PTP4A3/PRL-3) promotes the aggressiveness of human uveal melanoma through dephosphorylation of CRMP2

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-39643-y

Abstract: Uveal melanoma (UM) is an aggressive tumor in which approximately 50% of patients develop metastasis. Expression of the PTP4A3 gene, encoding a phosphatase, is predictive of poor patient survival. PTP4A3 expression in UM cells increases… read more here.

Keywords: ptp4a3; crmp2; tyrosine phosphatase; protein tyrosine ... See more keywords

De novo non-synonymous DPYSL2 (CRMP2) variants in two patients with intellectual disabilities and documentation of functional relevance through zebrafish rescue and cellular transfection experiments.

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recommendations! Published in 2022 at "Human molecular genetics"

DOI: 10.1093/hmg/ddac166

Abstract: Collapsin response mediator protein 2 (Crmp2) is an evolutionarily well-conserved tubulin-binding cytosolic protein that plays critical roles in the formation of neural circuitry in model organisms including zebrafish and rodents. No clinical evidence that CRMP2… read more here.

Keywords: novo non; non synonymous; two patients; transfection experiments ... See more keywords

Lacosamide modulates collapsin response mediator protein 2 and inhibits mossy fiber sprouting after kainic acid-induced status epilepticus

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recommendations! Published in 2018 at "NeuroReport"

DOI: 10.1097/wnr.0000000000001123

Abstract: Mossy fiber sprouting (MFS) and neuronal loss are important pathological features of chronic epilepsy closely related to the development of spontaneous recurrent seizures. However, the pathological mechanism of MFS remains unclear. Collapsin response mediator protein… read more here.

Keywords: protein; fiber sprouting; crmp2; status epilepticus ... See more keywords