Crocetin Imparts Antiproliferative Activity via Inhibiting STAT3 Signaling in Hepatocellular Carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "IUBMB life"
DOI: 10.1002/iub.2555
Abstract: STAT3 is a key oncogenic transcription factor, often overactivated in several human cancers including hepatocellular carcinoma (HCC). STAT3 modulates the expression of genes that are connected with cell proliferation, antiapoptosis, metastasis, angiogenesis, immune evasion in… read more here.
Keywords: hepatocellular carcinoma; hcc cells; stat3; crocetin ... See more keywords
Crocetin attenuates spared nerve injury-induced neuropathic pain in mice.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2017.08.007
Abstract: Crocetin is the main component of saffron and exhibits anti-oxidative and anti-inflammatory effects. Neuroinflammation and oxidative stress have been recognized to play a crucial role in the pathogenesis of neuropathic pain. We investigated the effect… read more here.
Keywords: spared nerve; crocetin; sni; neuropathic pain ... See more keywords
Crocetin restores diabetic endothelial progenitor cell dysfunction by enhancing NO bioavailability via regulation of PI3K/AKT‐eNOS and ROS pathways
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.05.021
Abstract: Aims: Endothelial progenitor cell (EPC) dysfunction underlies a critical risk factor in diabetic vascular complications due to function defect in restoring endothelium injury. Crocetin has attracted increasing attention in several vascular‐related diseases. In present study,… read more here.
Keywords: dysfunction; crocetin; pi3k akt; akt enos ... See more keywords
Protective efficacy of crocetin and its nanoformulation against cyclosporine A‐mediated toxicity in human embryonic kidney cells
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.11.027
Abstract: Aim: This study is aimed to formulate crocetin‐loaded lipid Nanoparticles (NPs) and to evaluate its antioxidant properties in a cyclosporine A‐mediated toxicity in Human Embryonic Kidney (HEK‐293) cells in vitro. Main methods: Crocetin‐loaded NPs were… read more here.
Keywords: cyclosporine mediated; mediated toxicity; crocetin; crocetin loaded ... See more keywords
Crocetin treatment inhibits proliferation of colon cancer cells through down-regulation of genes involved in the inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2017.04.005
Abstract: Background The current study was designed to investigate the effect of crocetin on the proliferation inhibition of colon cancer cells and the underlying mechanism. Methods MTT assay showed inhibition of proliferation of colon cancer cells… read more here.
Keywords: treatment; colon cancer; crocetin; cancer cells ... See more keywords
Regulated preparation of crocin-1 or crocin-2' triggered by the co-solvent DMSO using Bs-GT/At-SuSy one-pot reaction.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b05000
Abstract: Crocins are the primary coloring ingredients of saffron. The low-glycosylated members of this compound family, such as crocin-1(crocetin mono-glucosyl ester) and crocin-2' (crocetin di-glucosyl ester), are rarely distributed in nature and attracting interest in their… read more here.
Keywords: pot reaction; crocetin; crocin crocin; one pot ... See more keywords
Heterologous biosynthesis and manipulation of crocetin in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2017 at "Microbial Cell Factories"
DOI: 10.1186/s12934-017-0665-1
Abstract: BackgroundDue to excellent performance in antitumor, antioxidation, antihypertension, antiatherosclerotic and antidepressant activities, crocetin, naturally exists in Crocus sativus L., has great potential applications in medical and food fields. Microbial production of crocetin has received increasing… read more here.
Keywords: biosynthesis; saccharomyces cerevisiae; production; crocetin ... See more keywords
Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats
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DOI: 10.2147/dddt.s247947
Abstract: Purpose Arsenic trioxide (ATO) has been shown to induce hepatic injury. Crocetin is a primary constituent of saffron, which has been verified to have antioxidant and anti-inflammatory effects. In the current experiment, we evaluated the… read more here.
Keywords: ato induced; induced hepatic; hepatic injury; crocetin ... See more keywords
Crocetin Overproduction in Engineered Saccharomyces cerevisiae via Tuning Key Enzymes Coupled With Precursor Engineering
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.578005
Abstract: Crocetin, an important natural carotenoid dicarboxylic acid with high pharmaceutical values, has been successfully generated from glucose by engineered Saccharomyces cerevisiae in our previous study. Here, a systematic optimization was executed for crocetin overproduction in… read more here.
Keywords: saccharomyces cerevisiae; crocetin titer; crocetin; crocetin overproduction ... See more keywords
Changes of Crocin and Other Crocetin Glycosides in Saffron Through Cooking Models, and Discovery of Rare Crocetin Glycosides in the Yellow Flowers of Freesia Hybrida
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.885412
Abstract: Crocetin glycosides such as crocin are noted as functional food materials since the preventive effects of crocin have been reported against chronic disease and cancer. However, it is unclear how these apocarotenoids are structurally changed… read more here.
Keywords: crocetin; crocetin glycosides; yellow flowers; freesia hybrida ... See more keywords
Sericin/crocetin micro/nanoparticles for nucleus pulposus cells regeneration: An “active” drug delivery system
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1129882
Abstract: Introduction: Initiation and progression of intervertebral disk degeneration are linked to oxidative stress, with reactive oxygen species being a key factor. Therefore, as a potentially novel approach able to regenerate the damaged intervertebral disk, this… read more here.
Keywords: crocetin; delivery system; drug delivery; nucleus pulposus ... See more keywords