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   Articles with "crocin" as a keyword



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Crocin treatment promotes the oxidative stress and apoptosis in human thyroid cancer cells FTC‐133 through the inhibition of STAT/JAK signaling pathway

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recommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"

DOI: 10.1002/jbt.22608

Abstract: Thyroid cancer is the most frequent endocrine malignancy, which accounts for nearly 1% of all the cancer worldwide. Crocin has a diverse biological function, such as anti‐cancer, anti‐inflammatory and antioxidant functions, specifically in the respiratory… read more here.

Keywords: apoptosis; ftc 133; thyroid cancer; cancer ... See more keywords

Crocin Attenuates Nrf2/GPX4 Mediated Ferroptosis in Obstructive Nephropathy by Selectively Targeting MKK4

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recommendations! Published in 2025 at "Phytotherapy Research"

DOI: 10.1002/ptr.70092

Abstract: Renal fibrosis is a critical pathogenesis of chronic kidney disease (CKD). Crocin, an active compound derived from saffron ( Crocus sativus L.), exhibits potent antioxidant and renal protection properties. However, the effects of crocin on… read more here.

Keywords: crocin; mkk4; renal fibrosis; ferroptosis ... See more keywords

Crocin alleviates cognitive impairment associated with atherosclerosis via improving neuroinflammation in LDLR−/− mice fed a high‐fat/cholesterol diet

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recommendations! Published in 2022 at "Phytotherapy Research"

DOI: 10.1002/ptr.7384

Abstract: Crocin has been extensively investigated in treating neurodegenerative diseases. However, its effect on cognitive impairment associated with atherosclerosis remains unknown. The present study aimed to explore the potential mechanism of crocin on cognitive impairment in… read more here.

Keywords: cognitive impairment; associated atherosclerosis; crocin; impairment associated ... See more keywords

Protective effect of crocin on peroxidation‐induced oxidative stress and apoptosis in IPEC‐J2 cells

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recommendations! Published in 2024 at "Environmental Toxicology"

DOI: 10.1002/tox.24216

Abstract: The antioxidant properties of crocin are attracting interest, yet the underlying mechanisms by which crocin mitigates oxidative stress‐induced intestinal damage have not been determined. This study aimed to elucidate the effects of crocin on oxidative… read more here.

Keywords: crocin; stress; oxidative stress; induced oxidative ... See more keywords

Crocin Improves Diabetes-Induced Oxidative Stress via Downregulating the Nox-4 in Myocardium of Diabetic Rats.

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recommendations! Published in 2021 at "Advances in experimental medicine and biology"

DOI: 10.1007/978-3-030-73234-9_18

Abstract: BACKGROUND Oxidative stress has a crucial role in the pathophysiology of cardiac dysfunction in the diabetic milieu. Crocin is a natural compound that acts as an antioxidant which could potentially ameliorate oxidative damages in various… read more here.

Keywords: myocardium diabetic; diabetic rats; myocardium; diabetes induced ... See more keywords

The effect of Crocin on TFAM and PGC-1α expression and Catalase and Superoxide dismutase activities following cholestasis-induced neuroinflammation in the striatum of male Wistar rats.

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recommendations! Published in 2021 at "Metabolic brain disease"

DOI: 10.1007/s11011-021-00748-x

Abstract: Bile secretion is a physiological function that is disrupted following Bile Duct Ligation (BDL) and induces cholestasis. Cholestasis is a bile flow reduction that induces apoptosis, oxidative stress, and inflammation, and alters the expression of… read more here.

Keywords: tfam pgc; neuroinflammation; pgc; crocin ... See more keywords

Crocin mitigates γ-rays-induced hepatic toxicity in rats

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recommendations! Published in 2019 at "Environmental Science and Pollution Research"

DOI: 10.1007/s11356-019-04724-y

Abstract: AbstractCrocin (C44H64O24) is an isolated bioactive molecule of saffron extract. It has different pharmacological effects such as antioxidant and anti-inflammatory activities. In the present study, radioprotective property of crocin was investigated in the rat liver.… read more here.

Keywords: necrosis; group showed; toxicity; crocin ... See more keywords

Transdermal Delivery of Crocin Using Bacterial Nanocellulose Membrane

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recommendations! Published in 2019 at "Fibers and Polymers"

DOI: 10.1007/s12221-019-9076-8

Abstract: This work reports the inclusion of crocin (an active agent of saffron) into bacterial nanocellulose (BNC) membrane for transdermal drug delivery. The BNC showed good uptake of the crocin based on the swelling studies and… read more here.

Keywords: delivery crocin; bnc; bacterial nanocellulose; crocin ... See more keywords

Crocin, a carotenoid, suppresses spindle microtubule dynamics and activates the mitotic checkpoint by binding to tubulin

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recommendations! Published in 2019 at "Biochemical Pharmacology"

DOI: 10.1016/j.bcp.2019.01.023

Abstract: Graphical abstract Figure. No caption available. &NA; Crocin, a constituent of the saffron spice, exhibits promising antitumor activity in animal models and also inhibits the proliferation of several types of cancer cells in culture. Recently,… read more here.

Keywords: microtubule; spindle microtubule; microtubule dynamics; crocin ... See more keywords

Crocin alleviates coronary atherosclerosis via inhibiting lipid synthesis and inducing M2 macrophage polarization

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recommendations! Published in 2018 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2017.11.037

Abstract: ABSTRACT Atherosclerosis is a chronic inflammatory disease arising from an imbalance in lipid levels and the accumulation of cholesterol‐laden macrophages in the artery wall. Crocin is an active ingredient of Crocus sativus L. This study… read more here.

Keywords: crocin; macrophage polarization; atherosclerosis; coronary atherosclerosis ... See more keywords

Crocin-I alleviates the depression-like behaviors probably via modulating "microbiota-gut-brain" axis in mice exposed to chronic restraint stress.

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recommendations! Published in 2020 at "Journal of affective disorders"

DOI: 10.1016/j.jad.2020.07.041

Abstract: BACKGROUND Depressive disorder is rapidly advancing in the worldwide, and therapeutic strategy through "gut-brain" axis has been proved to be effective. Crocin, has been found to have antidepressant activity. However, there is no thorough research… read more here.

Keywords: crocin; depression; gut brain; brain axis ... See more keywords