Crocin treatment promotes the oxidative stress and apoptosis in human thyroid cancer cells FTC‐133 through the inhibition of STAT/JAK signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22608
Abstract: Thyroid cancer is the most frequent endocrine malignancy, which accounts for nearly 1% of all the cancer worldwide. Crocin has a diverse biological function, such as anti‐cancer, anti‐inflammatory and antioxidant functions, specifically in the respiratory… read more here.
Keywords: apoptosis; ftc 133; thyroid cancer; cancer ... See more keywords
Crocin alleviates cognitive impairment associated with atherosclerosis via improving neuroinflammation in LDLR−/− mice fed a high‐fat/cholesterol diet
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7384
Abstract: Crocin has been extensively investigated in treating neurodegenerative diseases. However, its effect on cognitive impairment associated with atherosclerosis remains unknown. The present study aimed to explore the potential mechanism of crocin on cognitive impairment in… read more here.
Keywords: cognitive impairment; associated atherosclerosis; crocin; impairment associated ... See more keywords
Crocin Improves Diabetes-Induced Oxidative Stress via Downregulating the Nox-4 in Myocardium of Diabetic Rats.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-73234-9_18
Abstract: BACKGROUND Oxidative stress has a crucial role in the pathophysiology of cardiac dysfunction in the diabetic milieu. Crocin is a natural compound that acts as an antioxidant which could potentially ameliorate oxidative damages in various… read more here.
Keywords: myocardium diabetic; diabetic rats; myocardium; diabetes induced ... See more keywords
The effect of Crocin on TFAM and PGC-1α expression and Catalase and Superoxide dismutase activities following cholestasis-induced neuroinflammation in the striatum of male Wistar rats.
Sign Up to like & getrecommendations! Published in 2021 at "Metabolic brain disease"
DOI: 10.1007/s11011-021-00748-x
Abstract: Bile secretion is a physiological function that is disrupted following Bile Duct Ligation (BDL) and induces cholestasis. Cholestasis is a bile flow reduction that induces apoptosis, oxidative stress, and inflammation, and alters the expression of… read more here.
Keywords: tfam pgc; neuroinflammation; pgc; crocin ... See more keywords
Crocin mitigates γ-rays-induced hepatic toxicity in rats
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-019-04724-y
Abstract: AbstractCrocin (C44H64O24) is an isolated bioactive molecule of saffron extract. It has different pharmacological effects such as antioxidant and anti-inflammatory activities. In the present study, radioprotective property of crocin was investigated in the rat liver.… read more here.
Keywords: necrosis; group showed; toxicity; crocin ... See more keywords
Transdermal Delivery of Crocin Using Bacterial Nanocellulose Membrane
Sign Up to like & getrecommendations! Published in 2019 at "Fibers and Polymers"
DOI: 10.1007/s12221-019-9076-8
Abstract: This work reports the inclusion of crocin (an active agent of saffron) into bacterial nanocellulose (BNC) membrane for transdermal drug delivery. The BNC showed good uptake of the crocin based on the swelling studies and… read more here.
Keywords: delivery crocin; bnc; bacterial nanocellulose; crocin ... See more keywords
Crocin, a carotenoid, suppresses spindle microtubule dynamics and activates the mitotic checkpoint by binding to tubulin
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2019.01.023
Abstract: Graphical abstract Figure. No caption available. &NA; Crocin, a constituent of the saffron spice, exhibits promising antitumor activity in animal models and also inhibits the proliferation of several types of cancer cells in culture. Recently,… read more here.
Keywords: microtubule; spindle microtubule; microtubule dynamics; crocin ... See more keywords
Crocin alleviates coronary atherosclerosis via inhibiting lipid synthesis and inducing M2 macrophage polarization
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.11.037
Abstract: ABSTRACT Atherosclerosis is a chronic inflammatory disease arising from an imbalance in lipid levels and the accumulation of cholesterol‐laden macrophages in the artery wall. Crocin is an active ingredient of Crocus sativus L. This study… read more here.
Keywords: crocin; macrophage polarization; atherosclerosis; coronary atherosclerosis ... See more keywords
Crocin-I alleviates the depression-like behaviors probably via modulating "microbiota-gut-brain" axis in mice exposed to chronic restraint stress.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2020.07.041
Abstract: BACKGROUND Depressive disorder is rapidly advancing in the worldwide, and therapeutic strategy through "gut-brain" axis has been proved to be effective. Crocin, has been found to have antidepressant activity. However, there is no thorough research… read more here.
Keywords: crocin; depression; gut brain; brain axis ... See more keywords
Micellization and aggregation behavior of crocin with bovine serum albumin: A biophysical study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2018.05.035
Abstract: Abstract The interaction of bovine serum albumin (BSA) with a naturally occurring surfactant (trans-crocetin di-(β-D-gentiobiosyl) ester, crocin) was studied under biophysical conditions by using various techniques such as surface tensiometry, UV–visible spectrophotometery and fluorescence. Upon… read more here.
Keywords: crocin; bsa; serum albumin; bovine serum ... See more keywords
Regulated preparation of crocin-1 or crocin-2' triggered by the co-solvent DMSO using Bs-GT/At-SuSy one-pot reaction.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b05000
Abstract: Crocins are the primary coloring ingredients of saffron. The low-glycosylated members of this compound family, such as crocin-1(crocetin mono-glucosyl ester) and crocin-2' (crocetin di-glucosyl ester), are rarely distributed in nature and attracting interest in their… read more here.
Keywords: pot reaction; crocetin; crocin crocin; one pot ... See more keywords